PMID: 26320440Sep 1, 2015Paper

Treatment Outcome and Prognostic Factors for Malignant Skin Melanoma Treated with Radical Surgery

Asian Pacific Journal of Cancer Prevention : APJCP
Wojciech MajewskiJerzy Wydmanski

Abstract

To assess the treatment outcome in patients with malignant skin melanoma and prognostic factors for distant metastases (DM), disease-free survival (DFS) and overall survival (OS). A retrospective analysis was conducted on 113 patients with malignant skin melanoma (60 females, 53 males, average age-55 years) who were treated surgically. Primary treatment consisted of local excision. In 12 cases, it was accompanied by lymph node excision. In 93 (82%) cases, radicalization was necessary, which was either local only (19 cases) or accompanied by lymph node surgery/biopsy (74 cases). Possible prognostic factors such as Clark's stage and Breslow's depth of invasion, ulceration, average tumor dimensions, lymph nodes metastases (pN+), gender, tumor location and primary excision margins were considered. In 51 (45%) cases, treatment failure occurred. The 5-year DM rate was 47%, the 5-year DFS was 38%, and the 5-year OS was 56%. In the univariate analysis, the important factors with respect to at least one endpoint included Clark's stage, Breslow's depth of invasion, ulceration, average tumor dimensions, lymph nodes metastases, gender and primary tumor localization. The presence of metastasic nodes was the most important prognostic factor,...Continue Reading

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Apr 10, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Grażyna Kamińska-WinciorekAndrzej Tukiendorf

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Citations

Dec 15, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yu XinWilliam Ka Kei Wu

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