Treatment outcome in dually HIV-1 and HIV-2 coinfected patients living in Spain

AIDS
Silvia RequenaSpanish HIV-2 Study Group

Abstract

Whereas HIV-1 has spread globally, HIV-2 is mainly found in West Africa where dual HIV-1/HIV-2 coinfection is nowadays uncommon. Herein, we report the rate, main characteristics, and treatment outcomes of all dually infected patients living in Spain. We identified retrospectively all persons coinfected with HIV-1 recorded at the Spanish HIV-2 registry. Dual infection had been confirmed using PCR in plasma and/or cells, and/or using discriminatory serological tests. From a total of 373 individuals with HIV-2 recorded at the Spanish registry, 34 (9.1%) were coinfected with HIV-1. Compared with HIV-2 monoinfected persons, dually infected patients were more often male (67.6%), presented with lower median CD4 cell counts (204 cells/μl), and had developed more frequently AIDS events (26.5%). Although 61.7% came from West Africa, 6 (17.6%) were native Spaniards. HIV-1 non-B subtypes were recognized in 75% of coinfected patients, being the most prevalent CRF02_AG. At baseline, 45% of dually infected patients had undetectable plasma HIV-2 RNA. After a median follow-up of 32 (13-48) months on antiretroviral therapy, dually infected patients achieved undetectable viremia in 85% for HIV-1, in 80% for HIV-2; and in 70% for both viruses. Med...Continue Reading

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Citations

Jul 25, 2020·Nature Materials·Vicente SorianoCarmen de Mendoza
Apr 1, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dirk BerzowRicardo Camacho
Aug 17, 2020·Medicina clínica·Carmen de MendozaUNKNOWN en nombre del Grupo Español de Estudio del HTLV y VIH-2

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