Treatment Outcome of Epileptic Patients Receiving Antiepileptic Drugs in Ethiopia: A Systematic Review and Meta-Analysis.

Behavioural Neurology
Taklo Simeneh YazieMulugeta Molla

Abstract

The prevalence and incidence rate of epilepsy were found to be higher in low- and middle-income countries. Uncontrolled epilepsy has a high risk of disability, stigma, discrimination, human rights violations, and premature death. The available studies of controlled seizure in Ethiopia have showed inconsistent results which calls for systematic review and meta-analysis. Therefore, this review intended to show the pooled prevalence of controlled seizure among people with epilepsy receiving antiepileptic drugs at outpatient department. A systematic literature search was conducted using PubMed/Medline, Science Direct, PsycINFO, Hinnarri databases, and Google Scholar for grey literatures. Data were extracted with structured format prepared using Microsoft Excel and exported to Stata/MP 16.0 software for analyses. The I 2 test was used to check the heterogeneity between primary studies with a corresponding 95% confidence interval (CI). A total of 23 primary studies were included in the review showing the pooled prevalence of controlled seizure to be 46% (95% CI: 35, 56). A subgroup analysis of the primary studies showed a considerable variation in magnitude of seizure freedom by study regions, age groups, and seizure-free period. The...Continue Reading

References

Apr 1, 1997·Seizure : the Journal of the British Epilepsy Association·G LassouwJ Troost
Apr 16, 2014·Epilepsia·Robert S FisherSamuel Wiebe
Jan 4, 2015·BMJ : British Medical Journal·Larissa ShamseerUNKNOWN PRISMA-P Group
Oct 21, 2015·BMC Research Notes·Berhanu Boru BifftuNigusie Birhan Tebeje
Dec 16, 2017·The Cochrane Database of Systematic Reviews·Sarah J NevittAnthony G Marson
Feb 8, 2018·Annals of General Psychiatry·Kelelemua HaileMulugeta Nega
Nov 28, 2018·Scientific Reports·Yirga Legesse NiriayoSeid Ibrahim
Oct 20, 2020·Archives of public health = Archives belges de santé publique·Zelalem Belayneh, Birhanie Mekuriaw

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