Abstract
Dihydroartemisinin-piperaquine (DHA-PQ) is one of five WHO recommended artemisinin combination therapy (ACT) for the treatment of uncomplicated malaria. However, little was known on its post-registration safety and effectiveness in sub-Saharan Africa. DHA-PQ provides a long post-treatment prophylactic effect against re-infection; however, new infections have been reported within a few weeks of treatment, especially in children. This paper reports the clinical outcomes following administration of DHQ-PQ in real-life conditions in public health facilities in Burkina Faso, Ghana, Mozambique, and Tanzania for the treatment of confirmed uncomplicated malaria. An observational, non-comparative, longitudinal study was conducted on 10,591 patients with confirmed uncomplicated malaria visiting public health facilities within seven health and demographic surveillance system sites in four African countries (Ghana, Tanzania, Burkina Faso, Mozambique) between September 2013 and April 2014. Patients were treated with DHA-PQ based on body weight and followed up for 28 days to assess the clinical outcome. A nested cohort of 1002 was intensely followed up. Clinical outcome was assessed using the proportion of patients who reported signs and sym...Continue Reading
References
Jun 13, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Corine KaremaUmberto D'Alessandro
May 26, 2007·PLoS Clinical Trials·Moses R KamyaGrant Dorsey
Jul 31, 2007·Transactions of the Royal Society of Tropical Medicine and Hygiene·H Y MyintN J White
Nov 9, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Issaka ZongoJean Bosco Ouédraogo
Jan 9, 2008·Antimicrobial Agents and Chemotherapy·J TarningN J White
Jun 12, 2008·PloS One·Adoke YekaHasifa Bukirwa
Jul 1, 2009·Antimicrobial Agents and Chemotherapy·Joel TarningFrançois Nosten
Aug 21, 2009·Malaria Journal·Kasia StepniewskaJean-René Kiechel
Sep 18, 2010·Global Health Action·Ali SiéHeiko Becher
Aug 31, 2011·Antimicrobial Agents and Chemotherapy·Sam SalmanTimothy M E Davis
Sep 29, 2011·Antimicrobial Agents and Chemotherapy·Marcus J RijkenFrançois Nosten
Oct 7, 2011·The American Journal of Tropical Medicine and Hygiene·Piero OlliaroJulien Zwang
Nov 17, 2011·PLoS Medicine·UNKNOWN Four Artemisinin-Based Combinations (4ABC) Study Group
Jan 20, 2012·Clinical Pharmacology and Therapeutics·J TarningN Lindegardh
Jan 27, 2012·Malaria Journal·Julien ZwangPiero Olliaro
May 5, 2012·Malaria Journal·Emiliana TjitraUNKNOWN Trihono
Aug 11, 2012·Malaria Journal·Simon L CroftHan-Jong Rim
Aug 31, 2012·International Journal of Epidemiology·Abraham Rexford OduroFred Binka
Oct 10, 2012·International Journal of Epidemiology·Karim DerraHalidou Tinto
Mar 1, 2013·The Journal of Infectious Diseases·Darren J CreekSunil Parikh
Oct 26, 2013·International Journal of Epidemiology·Charfudin SacoorTacilta Nhampossa
Dec 7, 2013·PLoS Medicine·UNKNOWN WorldWide Antimalarial Resistance Network (WWARN) DP Study Group
Jan 15, 2014·International Journal of Epidemiology·Margaret GyapongFred N Binka
Jan 30, 2014·Malaria Journal·Bernhards R OgutuElizabeth Juma
Aug 19, 2014·PloS One·Issaka ZongoJean Bosco Ouédraogo
Nov 8, 2014·The Journal of Antimicrobial Chemotherapy·Stephanie E ReuterPiero L Olliaro
Mar 10, 2015·International Journal of Epidemiology·Sigilbert MremaHonorati Masanja
Apr 18, 2015·Malaria Journal·Rita BaidenFred Binka
Citations
Jul 3, 2016·Malaria Journal·Joaquín Pousibet-PuertoM Teresa Cabezas-Fernández
Nov 30, 2016·The FEBS Journal·Wenxuan XuShizhong Zheng
Nov 21, 2016·The Lancet Infectious Diseases·Quique Bassat, Clara Menéndez
Nov 8, 2019·Clinical Pharmacology and Therapeutics·Kevin C KobylinskiJoel Tarning
May 21, 2017·Oncotarget·Xinli ShiMingrui Zhou
Oct 5, 2016·Antimicrobial Agents and Chemotherapy·Justin A GreenStephan Duparc
Apr 22, 2020·Antimicrobial Agents and Chemotherapy·Thanaporn WattanakulJoel Tarning
Apr 22, 2017·Malaria Journal·Abdelrahim O MohamedElfatih M Malik
Oct 20, 2018·Malaria Journal·Mwaka A KakolwaAbdunoor M Kabanywanyi
May 4, 2018·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Alexander N O Dodoo
Feb 17, 2021·BMJ Open·Mohamadou SiribieSodiomon Bienvenu Sirima
Sep 29, 2020·Journal of Pharmaceutical Sciences·Kouadio Victorien KonanMircea Alexandru Mateescu
Sep 9, 2019·Médecine et maladies infectieuses·L EpelboinE Caumes