Treatment Outcomes of Mitomycin C-Augmented Trabeculectomy, Sub-Tenon Injection versus Soaked Sponges, after 3 Years of Follow-up: A Randomized Clinical Trial.

Ophthalmology. Glaucoma
Hamed EsfandiariIan P Conner

Abstract

To report the 3-year outcome of trabeculectomy with mitomycin C (MMC)-soaked sponges versus intra-Tenon injection of MMC in eyes with uncontrolled primary open-angle glaucoma. Randomized clinical trial. Eighty-two consecutive patients with uncontrolled primary open-angle glaucoma. Participants were randomized either to intra-Tenon injection of 0.1 ml of 0.01% MMC (TI group) or 0.02% subconjunctival application of MMC-soaked sponges (TS group). Patients were followed up for 3 years after surgery. The data for 73 eyes were included in the final analysis. The primary outcome measure was the surgical success, defined as intraocular pressure (IOP) more than 5 mmHg and <21 mmHg, and IOP reduction of 20% or more from baseline, no reoperation for glaucoma, and no loss of light perception vision. Secondary outcome measures were IOP, glaucoma medications, best-corrected visual acuity (VA), bleb morphologic features according to the Indiana Bleb Appearance Grading Scale, complications, and endothelial cell count changes. The cumulative probability of success at 3-year follow-up was 72.2% in the TI group and 65.1% in the TS group (P = 0.30). Uncontrolled IOP was the most common reason for failure. The mean preoperative IOP was 22.4±4.6 mmH...Continue Reading

Citations

Dec 17, 2020·Indian Journal of Ophthalmology·Devendra MaheshwariMohideen A Kadar
Jan 8, 2021·International Ophthalmology·Shaheryar Ahmed KhanUmair Razzaq Arain
Dec 17, 2020·Indian Journal of Ophthalmology·Devendra MaheshwariMohideen Abdul Kadar
Dec 17, 2020·Indian Journal of Ophthalmology·Brenda LatsahebChengchira Sangma

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