Treatment outcomes of patients with AJCC stage IVC nasopharyngeal carcinoma: benefits of primary radiotherapy

Japanese Journal of Clinical Oncology
Shyh-An YehEng-Yen Huang

Abstract

There is no agreement on the optimal management of patients initially presenting with metastatic nasopharyngeal carcinoma. This study was performed to investigate the treatment outcomes and to assess whether radiotherapy to the primary tumors has survival benefits. From 1993 to 2001, 806 consecutive patients with histology-proven nasopharyngeal carcinoma were registered at our department. Among them, 125 patients had distant metastases and fulfilled the criteria for stage IVC of the 1997 American Joint Committee on Cancer staging system. Tumor histology according to the World Health Organization classification was Type 2 in 67 patients and Type 3 in 58 patients. The most common site of initial metastasis was bone. A total of 28 patients refused any treatment, 39 received chemotherapy alone and 58 had radiotherapy to the primary tumor sites alone. The 1 year overall survival rates were 25, 36 and 48% for patients with no treatment, chemotherapy and radiotherapy, respectively. In multivariate analysis, age of diagnosis and treatment modality were confirmed as independent prognostic factors for overall survival. Based on our results, radiotherapy to the primary tumor sites could be considered for patients with stage IVC nasopharyn...Continue Reading

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Citations

Feb 14, 2013·Drug Design, Development and Therapy·Lu ZhangHai-Qiang Mai
Nov 12, 2013·Chinese Journal of Cancer·Ming-Yuan ChenChao-Nan Qian
Jun 11, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yu ZhuYi Lu
Aug 30, 2017·Journal of Cancer Research and Clinical Oncology·Jeremy CheeChwee Ming Lim
Mar 27, 2019·Journal of the National Cancer Institute·Quynh Thu LeShakun Malik
Jan 18, 2019·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Xue-Song SunHai-Qiang Mai
Jun 2, 2020·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Eduardo NettoMargarida Roldão
Jun 6, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Honggen LiuYingjie Jia
Aug 19, 2021·BMJ Case Reports·Sehrish AbrarRabia Tahseen

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