Treatment outcomes of patients with stage II pure endometrioid-type endometrial cancer: a Taiwanese Gynecologic Oncology Group (TGOG-2006) retrospective cohort study

Journal of Gynecologic Oncology
Hung-Chun FuMing-Shyen Yen

Abstract

Choice of hysterectomy and adjuvant treatment for International Federation of Gynecology and Obstetrics (FIGO) 2009 stage II endometrioid endometrial cancer (EEC) is still controversial. Aims of this study were to evaluate survival benefits and adverse effects of different hysterectomies with or without adjuvant radiotherapy (RT), and to identify prognostic factors. The patients at 14 member hospitals of the Taiwanese Gynecologic Oncology Group from 1992 to 2013 were retrospectively investigated. Patients were divided into simple hysterectomy (SH) alone, SH with RT, radical hysterectomy (RH) alone, and RH with RT groups. Endpoints were recurrence-free survival (RFS), overall survival (OS), disease-specific survival (DSS), adverse effects and prognostic factors for survival. Total of 246 patients were enrolled. The 5-year RFS, OS, DSS and recurrence rates for the entire cohort were 89.5%, 94.3%, 96.2% and 10.2%, respectively. Patients receiving RH had more adverse effects including blood loss (p<0.001), recurrent urinary tract infections (p=0.013), and leg lymphedema (p=0.038). Age over 50-year (HR=9.2; 95% confidence interval [CI]=1.2-70.9) and grade 3 histology (HR=7.28; 95% CI=1.45-36.6) were independent predictors of OS. Gra...Continue Reading

References

Mar 22, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·E SartoriV Zanagnolo
Dec 13, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·W T CreasmanS Pecorelli
May 2, 2007·Obstetrics and Gynecology·David E CohnJeffrey M Fowler
Jan 13, 2009·American Journal of Obstetrics and Gynecology·Jason D WrightThomas J Herzog
Apr 7, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·William Creasman
Apr 2, 2010·Journal of Korean Medical Science·Taek Sang LeeD Scott McMeekin
May 25, 2010·Japanese Journal of Clinical Oncology·Chun-Ju ChiangUNKNOWN Taiwan Cancer Registry Task Force
Jul 25, 2012·Obstetrics and Gynecology·Joel I Sorosky
Sep 11, 2012·Journal of the National Cancer Institute·Anthony KongTheresa A Lawrie
Apr 25, 2014·Journal of Gynecologic Oncology·Jonathan E FrandsenDavid K Gaffney
Jun 7, 2014·Gynecologic Oncology·William M BurkeUNKNOWN Society of Gynecologic Oncology Clinical Practice Committee
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Feb 18, 2015·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Ulas SolmazMuzaffer Sanci
Sep 21, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Nejat OzgulTayup Simsek
Nov 1, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·W T CreasmanS Pecorelli

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Methods Mentioned

BETA
dissection
hysterectomy
hysterectomies

Software Mentioned

SPSS

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