Treatment Outcomes of Pediatric Status Epilepticus in a Tertiary Pediatric Intensive Care Unit.

Pediatric Emergency Care
Dilek CavusogluBerrak Sarioglu

Abstract

Status epilepticus is associated with high rates of morbidity and mortality; thus, early diagnosis and proper treatment are crucial. We aimed to study the etiology, clinical features, and treatment among pediatric patients with convulsive status epilepticus. The medical records of 100 patients were retrospectively obtained from pediatric intensive care unit. Etiology, clinical features, and treatment were interpreted by using Fisher exact test, χ2 test, and Spearman ρ correlation coefficient. Seizures had stopped with the first-, second-, and third-line treatment in 29%, 36%, and 35% of the patients, respectively. Only phenytoin treatment was efficient; it has 32.3% rate in second-line treatment. Whereas mortality rate was 10%, morbidity rate was 14% during the follow-up. Epilepsy, hemiparesis, spastic tetraparesis, and mental retardation developed. Mortality was significantly much more in the patients with refractory seizure and cerebral palsy. Development of mental retardation was much higher in the male sex. Phenytoin is still one of the most efficient antiepileptic drugs. If the duration of status epilepticus can be shortened by prompt treatment, neurological complications may be prevented.

References

Apr 1, 1995·Pediatric Neurology·B K AlldredgeD M Ferriero
Sep 9, 2005·Epilepsy & Behavior : E&B·Ali Akbar Asadi-Pooya, Alie Poordast
Apr 20, 2007·Epilepsia·Itsuko NishiyamaKiyoshi Fujimoto
Jul 20, 2007·Epilepsia·Miquel Raspall-ChaureRod C Scott
Dec 21, 2007·Epilepsia·Florise A C P Lambrechtsen, Jeffrey R Buchhalter
Aug 25, 2009·Seizure : the Journal of the British Epilepsy Association·Sandya TirupathiDavid W Webb
Nov 26, 2009·Pediatric Neurology·Kuang-Lin LinHuei-Shyong Wang
May 22, 2010·Pediatrics International : Official Journal of the Japan Pediatric Society·Gulser Esen BesliMehtap Haktanir Abul
Aug 24, 2010·Seminars in Pediatric Neurology·Nicholas S AbendDennis J Dlugos
Jan 5, 2011·Seizure : the Journal of the British Epilepsy Association·Eylem Ulas SazHasan Tekgul
Apr 25, 2012·Neurocritical Care·Gretchen M BrophyUNKNOWN Neurocritical Care Society Status Epilepticus Guideline Writing Committee
Mar 30, 2013·Critical Care Clinics·Ryan Wilkes, Robert C Tasker
Oct 12, 2014·Current Opinion in Pediatrics·Nicholas S Abend, Tobias Loddenkemper
Oct 15, 2014·Current Opinion in Pediatrics·Eric T Payne, Cecil D Hahn
Feb 20, 2015·Developmental Medicine and Child Neurology·Kate Himmelmann, Valter Sundh
Apr 22, 2015·Journal of Child Neurology·Eman F HalawaHala A Shaheen
Nov 21, 2015·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Samir ShahNarayan Prasad

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

JAMA : the Journal of the American Medical Association
Psychiatrie, Neurologie, und medizinische Psychologie
H Schulz
Developmental Medicine and Child Neurology
S Wolff
© 2021 Meta ULC. All rights reserved