Treatment outcomes of recommended first-line antiretroviral regimens in resource-limited clinics

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Anthony AmorosoRobert R Redfield

Abstract

Although used globally, little data exist on the efficacy of nevirapine (NVP) used in combination with tenofovir (TDF)/emtricitabine or lamivudine (XTC), and no large randomized prospective control trials exists comparing this combination with efavirenz (EFV)/TDF/(XTC). As part of the AIDSRelief program, a retrospective review of patient medical chart information along with a cross-sectional viral load, and adherence measurement was conducted between 2004 and 2009. An on-treatment analysis excluded patients who died, transferred out of care, or were lost to follow-up. A switch of antiretrovirals for any reason was considered a failure in the intent-to-treat analysis. Patients with only clinically relevant reasons for switching such as toxicity, adverse effects, viral failure or clinical/immunological failure, lost to follow-up, and death were considered failures as part of the modified-intent-to-treat analysis. Step-wise multiple regression analysis was used to identify variables that were associated with viral suppression. A random sample of 3862 patients met criteria and were included in this analysis. In the on-treatment analysis, older age (P < 0.004) and baseline CD4 <100 cells per cubic millimeter (P < 0.021) were the mos...Continue Reading

References

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May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Navjot Singh, Jubbin Jagan Jacob
Sep 10, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert R Redfield, J Scott Morrow
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Citations

Jul 13, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ankur Gupta-WrightStephen D Lawn
Mar 8, 2014·AIDS Patient Care and STDs·Brian C Zanoni, Kenneth H Mayer
Nov 13, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kimberly K ScarsiUNKNOWN Harvard/APIN PEPFAR Team
Jun 19, 2015·The Journal of Antimicrobial Chemotherapy·María RupérezRoger Paredes
Apr 15, 2016·The Journal of Antimicrobial Chemotherapy·Claudia HawkinsWafaie Fawzi
Apr 2, 2016·The Journal of Infectious Diseases·Andrew N PhillipsTimothy B Hallett
Oct 5, 2017·Revista da Associação Médica Brasileira·Antonio Carlos Policarpo Carmo Sá BandeiraLara Gurgel Fernandes Távora
Mar 24, 2016·Antimicrobial Agents and Chemotherapy·Fred KyeyuneMiguel E Quiñones-Mateu
Jan 14, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marcelo WolffUNKNOWN Caribbean, Central and South America Network for HIV Epidemiology
Jan 14, 2020·Journal of the International Association of Providers of AIDS Care·Suzy MariaZubairi Djoerban

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