Treatment patterns and burden of behavioral disturbances in patients with dementia in the United States: a claims database analysis

BMC Neurology
Myrlene Sanon AigbogunHoward Fillit

Abstract

Although patients with dementia frequently experience neuropsychological symptoms (NPS) such as agitation, which profoundly impacts patients, caregivers, and the healthcare system, few studies have evaluated the associated burden of agitation or agitation-related symptoms in dementia. This retrospective analysis of claims data from the Truven Health MarketScan® database (2012-2015) compared clinical characteristics, treatment patterns, healthcare resource utilization, and costs among patients with dementia with behavioral disturbances (BD) versus patients with dementia without BD. Existing BD diagnosis codes 294.11 or 294.21 were used as a means to identify patients with agitation/agitation-related symptoms. From a starting sample of 6.4 million beneficiaries, 103,402 patients with dementia were identified, of whom 16,440 (16%) had BD during an average of 17 months of follow-up. Patients with BD had significantly more medical and psychiatric comorbidities and greater comedication use (i.e., antidementia drugs, antidepressants, and antipsychotics; all values, P < .0001) compared with patients without BD. A significantly greater number of hospitalizations, hospital days, outpatient hospital/clinic visits, number of skilled nursin...Continue Reading

References

Jun 6, 2000·Journal of Affective Disorders·C BallardR Perry
Mar 12, 2004·Primary Care Companion to the Journal of Clinical Psychiatry·Abhilash K. Desai, George T. Grossberg
Sep 13, 2005·Journal of Alzheimer's Disease : JAD·Jerrold HillRobert Futterman
Dec 3, 2005·International Journal of Geriatric Psychiatry·Philippe ThomasJean-Pierre Clément
Jan 20, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·S BanerjeeM Knapp
Sep 7, 2006·International Journal of Geriatric Psychiatry·Nathan HerrmannElizabeth Nguyen
Jun 5, 2007·Alzheimer Disease and Associated Disorders·Kathryn L LunettaUNKNOWN MIRAGE Study Group
Nov 7, 2007·Archives of General Psychiatry·Robert A RosenheckUNKNOWN Clinical Antipsychotic Trial of Intervention Effectiveness-Alzheimer's Disease (CATIE-AD) investigators
Dec 12, 2007·Archives of Neurology·Nikolaos ScarmeasYaakov Stern
Jun 30, 2009·Alzheimer Disease and Associated Disorders·Denys T LauSandra Weintraub
Jan 26, 2010·International Psychogeriatrics·Serge GauthierConstantine Lyketsos
Sep 3, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Somaia MohamedLon S Schneider
Nov 17, 2011·Alzheimer Disease and Associated Disorders·David K JohnsonJeffrey M Burns
Apr 17, 2012·Clinics in Geriatric Medicine·Bhavik M Shah, Emily R Hajjar
May 16, 2012·Frontiers in Neurology·J CerejeiraE B Mukaetova-Ladinska
May 31, 2012·Current Psychiatry Reports·Abhilash K DesaiGeorge T Grossberg
Sep 25, 2012·Journal of Alzheimer's Disease : JAD·Carmen EchávarriFrans R J Verhey
Feb 20, 2014·JAMA : the Journal of the American Medical Association·Anton P PorsteinssonUNKNOWN CitAD Research Group
Jul 26, 2014·The British Journal of Psychiatry : the Journal of Mental Science·Elizabeth L SampsonLouise Jones
Mar 4, 2015·BMJ : British Medical Journal·Helen C KalesConstantine G Lyketsos
Mar 12, 2019·International Psychogeriatrics·Milena AnatchkovaMyrlene Sanon Aigbogun

❮ Previous
Next ❯

Citations

Jul 28, 2019·International Journal of Molecular Sciences·Federico AmbrogioFiammetta Monacelli
Mar 12, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Apr 2, 2020·International Psychogeriatrics·Claire V BurleyHenry Brodaty
Feb 28, 2020·JAD Reports·Karel Kostev, Galina Osina
Mar 29, 2020·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Tannahill GlenPatricia Espe-Pfeifer
Mar 24, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Aug 11, 2020·Journal of the American Medical Directors Association·Robert EspinosaDaniel Weintraub
Aug 10, 2021·JAD Reports·Wenjun ZhongKai-Li Liaw
Jul 22, 2021·International Journal of Geriatric Psychiatry·Howard FillitGeorge Grossberg
Sep 3, 2021·Journal of the American Medical Directors Association·David C MohrKelly Vance

❮ Previous
Next ❯

Software Mentioned

SAS Enterprise

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here