Treatment patterns and health care costs of mebeverine-treated IBS patients: a case-control study

Pharmacoepidemiology and Drug Safety
Wim G GoettschR M Herings

Abstract

Irritable bowel syndrome (IBS) is a functional disorder affecting the quality of life of patients. In the Netherlands, mebeverine is currently the only medical treatment registered for IBS, although its efficacy is considered disputable. To assess treatment patterns and associated health care cost in mebeverine users relative to matched controls. A matched case-control study was performed using pharmacy data. Cases were mebeverine users as proxy for IBS patients. Controls were non-mebeverine users and matched to cases by age, gender and pharmacy. Prevalence and incidence of mebeverine use, concomitant drug use and hospitalizations were assessed in 3431 cases and 3431 controls. Concomitant drug use and hospitalizations was also assessed in a subgroup of 1222 users of mebeverine and laxatives (proxy for constipation-IBS) and their controls. Twelve per 1000 residents were ever-dispensed mebeverine in 1998. One-third of these mebeverine users used laxatives concomitantly. Concomitant drug use and hospitalizations were increased in mebeverine users. The odds ratio for hospitalizations for gastrointestinal reasons was increased predominantly in mebeverine users with concomitant laxative use (OR:8.7; 95%CI [4.3-17.3]). Excess yearly c...Continue Reading

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Citations

Nov 28, 2012·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Leyla MohseninejadErik Buskens
Jul 18, 2006·Alimentary Pharmacology & Therapeutics·J TackG Fisher
Jun 11, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Michiel W van der LindenRon M C Herings
Dec 22, 2014·International Journal of Food Microbiology·Marie-Josée J MangenArie H Havelaar
Apr 12, 2006·European Journal of Gastroenterology & Hepatology·Maarten J ten BergRon M C Herings
Nov 5, 2019·The Journal of Dermatological Treatment·Jeremy K BraySteven R Feldman

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