Treatment patterns and outcomes among women with brain metastases from gynecologic malignancies

Gynecologic Oncology Reports
Kristen CaginoEloise Chapman-Davis

Abstract

Brain metastasis secondary to gynecologic malignancy is rare and has no definitive management guidelines. In this descriptive study, we aimed to identify prognostic factors and treatments that may be associated with longer overall survival. Patients with brain metastases from gynecologic malignancies were identified between 2004 and 2019 at two institutions. Descriptive statistics were performed using N (%) and median (interquartile range). Univariate cox proportional hazards regression was performed to evaluate the effect of different factors on overall survival. 32 patients presented with brain metastasis from gynecologic primaries (ovarian/fallopian tube/primary peritoneal n = 14, uterine n = 11, cervical n = 7). Median age of initial cancer diagnosis was 61 (34-79). At initial cancer diagnosis 83% of patients were Stage III/IV and underwent surgery (66%), chemotherapy (100%), and/or pelvic radiation (33%). Median time from initial cancer diagnosis to brain metastasis was 18 months. Treatment of brain metastasis with surgery and radiation compared to stereotactic radiosurgery or whole brain radiation therapy alone revealed a trend toward longer overall survival (p = 0.07). Time from initial cancer diagnosis to brain metastas...Continue Reading

References

Dec 18, 2001·Journal of Surgical Oncology·D S McMeekinR S Mannel
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Oct 9, 2013·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Xiaoyu NiuJoshua Z Press
Apr 21, 2016·Gynecologic Oncology·Stefano UccellaAndrea Mariani
Dec 1, 2017·Brain Tumor Research and Treatment·Seung Bin KimChae-Yong Kim
Dec 23, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul D BrownVinai Gondi
Aug 1, 2016·Open Journal of Obstetrics and Gynecology·Madiha A GilaniRussell J Schilder

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