Treatment performance measures affect clinical outcomes in patients with acute systolic heart failure: report from the Korean Heart Failure Registry

Circulation Journal : Official Journal of the Japanese Circulation Society
Young Jin YounKorHF Registry

Abstract

There is a paucity of data on the effects of adherence to treatment on outcomes for patients with acute heart failure (HF) in Korea. We used HF performance measures to evaluate overall adherence and whether this affects clinical outcomes. Among 3,466 patients in the Korean Heart Failure Registry, 1,527 patients with left ventricular systolic dysfunction (LVSD) who survived hospitalization were evaluated. Modified validated performance measures were defined as follows: use at discharge of angiotensin-converting enzyme inhibitor (ACEI), angiotensin-receptor II blocker (ARB), β-blocker or aldosterone receptor antagonist. Adherence to performance measures were as follows: ACEI or ARB at discharge, 68.0%; β-blocker at discharge, 40.9%; aldosterone receptor antagonist at discharge, 37.5%. On multivariate analysis, adherence to the measure of ACEI or ARB use at discharge was significantly associated with mortality (odds ratio (OR), 0.344; 95% confidence interval (CI), 0.123-0.964), readmission (OR, 0.180; 95%CI, 0.062-0.522) and mortality/readmission (OR, 0.297; 95%CI, 0.125-0.707) at 60 days and that for β-blocker with mortality (OR, 0.337; 95%CI, 0.147-0.774) at 1 year. For patients with LVSD in Korea, adherence to treatment perform...Continue Reading

References

Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn
Jun 2, 2001·The New England Journal of Medicine·M PackerUNKNOWN Carvedilol Prospective Randomized Cumulative Survival Study Group
Jan 5, 2002·The New England Journal of Medicine·J N CohnUNKNOWN Valsartan Heart Failure Trial Investigators
Apr 2, 2003·The New England Journal of Medicine·Bertram PittUNKNOWN Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study Investigators
Jan 12, 2005·Circulation·Todd M KoellingKeith D Aaronson
Apr 14, 2005·European Heart Journal·Michel KomajdaClaude Le Pen
Jul 13, 2005·Archives of Internal Medicine·Gregg C FonarowUNKNOWN ADHERE Scientific Advisory Committee, Study Group, and Investigators
Sep 27, 2006·European Heart Journal·Markku S NieminenUNKNOWN Heart Failure Association, European Society of Cardiology
Jan 4, 2007·JAMA : the Journal of the American Medical Association·Gregg C FonarowUNKNOWN OPTIMIZE-HF Investigators and Hospitals
May 2, 2007·Current Cardiology Reports·Gautam R ShroffMonica Colvin-Adams
Aug 21, 2007·Journal of the American College of Cardiology·Gregg C FonarowUNKNOWN OPTIMIZE-HF Investigators and Hospitals
Aug 1, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Miyuki Tsuchihashi-MakayaUNKNOWN JCARE-CARD Investigators
May 27, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Miyuki Tsuchihashi-MakayaUNKNOWN JCARE-CARD Investigators
Aug 25, 2010·Circulation·Latha P PalaniappanUNKNOWN Council on Cardiovascular Nursing
Jul 6, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Gregg C Fonarow
Oct 13, 2011·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Stephen P SchmaltzRobert M Wachter

❮ Previous
Next ❯

Citations

Jan 30, 2015·Current Medical Research and Opinion·Jamshed DalalBrian Tomlinson
Nov 8, 2014·PloS One·Claudia FischerEwout W Steyerberg
Mar 15, 2015·Journal of Telemedicine and Telecare·Riet DierckxAndrew L Clark
Feb 6, 2017·Korean Circulation Journal·Jong-Chan YounKyu-Hyung Ryu
May 27, 2015·European Journal of Heart Failure·Sivadasanpillai HarikrishnanUNKNOWN Trivandrum Heart Failure Registry
Oct 17, 2017·Journal of the Chinese Medical Association : JCMA·Hung-Yu ChangWei-Hsian Yin
Jun 11, 2019·Journal of the Chinese Medical Association : JCMA·Carolyn S P LamYanli Zhou
Nov 25, 2014·The Journal of Cardiovascular Nursing·Lisa C BratzkeKathleen A Dracup
May 3, 2019·Journal of Korean Medical Science·Min Soo AhnMyeong Chan Cho
Jul 30, 2015·European Journal of Heart Failure·Hiroaki ShimokawaYasuhiko Sakata
Mar 21, 2019·Journal of the Chinese Medical Association : JCMA·Hung-Yu ChangWei-Hsian Yin
May 2, 2021·The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology·Aashiq Ahamed ShukkoorArun Kaushik Ponnusamy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.