Treatment persistence among patients with immune-mediated rheumatic disease newly treated with subcutaneous TNF-alpha inhibitors and costs associated with non-persistence

Rheumatology International
Johan DalénSumesh Kachroo

Abstract

The main objective of this study was to describe real-world treatment persistence with subcutaneous tumor necrosis factor-alpha inhibitors (SC-TNFi) in patients with ankylosing spondylitis, psoriatic arthritis, or rheumatoid arthritis [collectively immune-mediated rheumatic disease, (IMRD)] in Sweden. A secondary objective was to describe potential effects on health care resource utilization (HCRU) cost from non-persistence. Patients were identified through filled prescriptions for adalimumab (ADA), etanercept (ETA), certolizumab pegol (CZP), and golimumab (GLM) between 5/6/2010 and 12/31/2012 from the Swedish Prescribed Drug Register. Persistence was estimated using survival analysis. Costs were derived from HCRU and comprised specialized outpatient care, inpatient care and non-disease-modifying antirheumatic drug medications. A total of 4903 patients were identified (ADA: 1823, ETA: 1704, CZP: 622, GLM: 754). Comparisons over 3 years showed that GLM had significantly higher persistence than ADA (p = 0.022) and ETA (p = 0.004). The mean difference in non-biologic HCRU costs between persistent and non-persistent patients was higher after compared to before the start of biologic therapy. SC-TNFi-naïve IMRD patients initiating tr...Continue Reading

References

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Citations

May 12, 2016·Current Rheumatology Reports·Luis Arturo Gutiérrez-González
Dec 10, 2016·Scandinavian Journal of Rheumatology·K J AaltonenT Sokka
Aug 26, 2017·Immunotherapy·Maria UrdanetaSonya Abraham
Jan 29, 2020·Current Medical Research and Opinion·Francisco de Assis AcurcioElham Rahme
Sep 16, 2019·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Axel SvedbomSumesh Kachroo
May 23, 2017·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·James E Frampton
Dec 1, 2020·Internal Medicine·Tetsuya NemotoHajime Ishikawa

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