Treatment persistence in paediatric and adolescent patients with psoriasis followed into young adulthood. From topical to systemic treatment: a prospective, longitudinal, observational cohort study of 448 patients.

The British Journal of Dermatology
F M BruinsM M B Seyger

Abstract

Although solely topical treatment often suffices, patients with psoriasis may require more intensive treatment (phototherapy and/or systemic treatments) to control their disease. However, in paediatric, adolescent and young adult patients, little is known about persistence of topical treatment and time until switch to systemic treatment. To determine the median time from psoriasis onset until (i) discontinuation of solely topical agents and (ii) switch to systemic treatment, and to identify patient characteristics associated with switching to systemic treatments. Data were extracted from the Child-CAPTURE registry, a prospective, observational cohort of patients with paediatric-onset psoriasis followed into young adulthood from 2008 to 2018. Data prior to inclusion in the registry were collected retrospectively. Median times were determined through Kaplan-Meier survival analyses. Cox regression analysis was used to identify patient characteristics associated with switch to systemic treatment. Of 448 patients, 62·3% stayed on solely topical treatment until data lock; 14·3% switched from topicals to phototherapy, but not to systemic treatment; and 23·4% switched to systemic treatment. The median time from psoriasis onset until di...Continue Reading

References

Jun 1, 1995·The British Journal of Dermatology·M S Lewis-Jones, A Y Finlay
May 1, 1994·Clinical and Experimental Dermatology·A Y Finlay, G K Khan
Oct 20, 2004·The British Journal of Dermatology·C L CarrollR Balkrishnan
Nov 11, 2009·Journal of the American Academy of Dermatology·Michelle E A de JagerMarieke M B Seyger
Apr 15, 2010·Dermatology : International Journal for Clinical and Investigative Dermatology·M E A de JagerM M B Seyger
Mar 6, 2012·The British Journal of Dermatology·A Y Finlay, M K A Basra
May 15, 2013·Actas dermo-sifiliográficas·S RosJ M Carrascosa
Jun 26, 2013·Current Problems in Dermatology·Peter L MatteiAlexa B Kimball
May 13, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·A SvedbomM Ståhle
Oct 28, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·M J van GeelM M B Seyger
May 31, 2015·Lancet·Wolf-Henning Boehncke, Michael P Schön
Jun 15, 2015·Paediatric Drugs·I M G J BronckersM M B Seyger
Oct 30, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Clemens PainsiPeter Wolf
Oct 28, 2016·The Journal of Dermatological Treatment·Mathias Tiedemann SvendsenHelle Johannessen
Sep 14, 2017·JAMA Dermatology·Inge M G J BronckersUNKNOWN Psoriasis Investigator Group (PsIG) of the Pediatric Dermatology Research Alliance and the European Working Group on Pediatr
Nov 10, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·J M P A van den ReekE M G J de Jong
Aug 14, 2018·The Journal of Dermatological Treatment·Inge M G J BronckersMarieke M B Seyger
Jan 4, 2019·The British Journal of Dermatology·G E van der KraaijP I Spuls Chair

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Citations

Sep 11, 2020·The British Journal of Dermatology·A Salman
Oct 6, 2020·The British Journal of Dermatology·K Reich

Dec 4, 2020·Annales de dermatologie et de vénéréologie·F Cambazard

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