Treatment planning for a small animal using Monte Carlo simulation

Medical Physics
James C L Chow, Michael K K Leung

Abstract

The development of a small animal model for radiotherapy research requires a complete setup of customized imaging equipment, irradiators, and planning software that matches the sizes of the subjects. The purpose of this study is to develop and demonstrate the use of a flexible in-house research environment for treatment planning on small animals. The software package, called DOSCTP, provides a user-friendly platform for DICOM computed tomography-based Monte Carlo dose calculation using the EGSnrcMP-based DOSXYZnrc code. Validation of the treatment planning was performed by comparing the dose distributions for simple photon beam geometries calculated through the Pinnacle3 treatment planning system and measurements. A treatment plan for a mouse based on a CT image set by a 360-deg photon arc is demonstrated. It is shown that it is possible to create 3D conformal treatment plans for small animals with consideration of inhomogeneities using small photon beam field sizes in the diameter range of 0.5-5 cm, with conformal dose covering the target volume while sparing the surrounding critical tissue. It is also found that Monte Carlo simulation is suitable to carry out treatment planning dose calculation for small animal anatomy with v...Continue Reading

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Citations

Oct 2, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Giovanni Lucignani
Mar 21, 2013·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·L WackP Zygmanski
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Jun 21, 2018·Physics in Medicine and Biology·Yi-Fang WangCheng-Shie Wuu
Mar 30, 2011·Physics in Medicine and Biology·R PidikitiT D Solberg
Nov 6, 2015·Physics in Medicine and Biology·James M P StewartDavid A Jaffray
Apr 20, 2019·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Pierre LansonneurLudovic De Marzi

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