Treatment regimens and glycosylated hemoglobin levels in youth with Type 1 and Type 2 diabetes: Data from SEARCH (United States) and YDR (India) registries.

Pediatric Diabetes
Anandakumar AmuthaViswanathan Mohan

Abstract

To compare treatment regimens and glycosylated hemoglobin (A1c) levels in Type 1 (T1D) and Type 2 diabetes (T2D) using diabetes registries from two countries-U.S. SEARCH for Diabetes in Youth (SEARCH) and Indian Registry of youth onset diabetes in India (YDR). The SEARCH and YDR data were harmonized to the structure and terminology in the Observational Medical Outcomes Partnership Common Data Model. Data used were from T1D and T2D youth diagnosed <20 years between 2006-2012 for YDR, and 2006, 2008, and 2012 for SEARCH. We compared treatment regimens and A1c levels across the two registries. There were 4003 T1D (SEARCH = 1899; YDR = 2104) and 611 T2D (SEARCH = 384; YDR = 227) youth. The mean A1c was higher in YDR compared to SEARCH (T1D:11.0% ± 2.9% vs 7.8% ± 1.7%, P < .001; T2D:9.9% ± 2.8% vs 7.2% ± 2.1%, P < .001). Among T1D youth in SEARCH, 65.1% were on a basal/bolus regimen, whereas in YDR, 52.8% were on once/twice daily insulin regimen. Pumps were used by 16.2% of SEARCH and 1.5% of YDR youth with T1D. Among T2D youth, in SEARCH and YDR, a majority were on metformin only (43.0% vs 30.0%), followed by insulin + any oral hypoglycemic agents (26.3% vs 13.7%) and insulin only (12.8% vs 18.9%), respectively. We found significan...Continue Reading

References

Sep 12, 2008·The New England Journal of Medicine·Rury R HolmanH Andrew W Neil
Mar 3, 2009·Diabetes Care·Dana DabeleaUNKNOWN SEARCH for Diabetes in Youth Study Group
Sep 17, 2009·Pediatric Diabetes·Marian RewersGeorgeanna J Klingensmith
Nov 13, 2009·Diabetes Care·Sanne G SwinnenJ Hans DeVries
Nov 13, 2009·Diabetes Technology & Therapeutics·Chidambarann SudhakaranViswanathan Mohan
May 22, 2010·Current Opinion in Pediatrics·Joshua S Borus, Lori Laffel
Sep 3, 2010·Diabetes Technology & Therapeutics·Jothydev KesavadevViswanathan Mohan
Oct 22, 2010·The Journal of Clinical Endocrinology and Metabolism·Kenneth C CopelandUNKNOWN TODAY Study Group
Mar 3, 2012·Journal of Pharmaceutical Sciences·Jayabharathi VaidyanathanChandrahas G Sahajwalla
May 1, 2012·The New England Journal of Medicine·UNKNOWN TODAY Study GroupFrancine Kaufman
Sep 11, 2012·Diabetes Care·Catherine PihokerUNKNOWN SEARCH for Diabetes in Youth Study Group
Jan 4, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Sep 13, 2013·Diabetes Care·Angela BadaruCatherine Pihoker
Oct 17, 2013·Diabetes Care·Allison B DartElizabeth A Sellers
Dec 5, 2013·Diabetes Research and Clinical Practice·Ambady RamachandranRonald Ching Wan Ma
May 6, 2014·JAMA : the Journal of the American Medical Association·Dana DabeleaUNKNOWN SEARCH for Diabetes in Youth Study
Jun 6, 2014·Diabetes·Jean M LawrenceUNKNOWN SEARCH for Diabetes in Youth Study Group
Jun 18, 2014·Diabetes Care·Jane L ChiangUNKNOWN Type 1 Diabetes Sourcebook Authors
Aug 8, 2014·Diabetes Technology & Therapeutics·Ranjit UnnikrishnanViswanathan Mohan
Nov 22, 2014·Diabetes Care·Richard F HammanUNKNOWN SEARCH for Diabetes in Youth Study Group
May 6, 2015·Indian Journal of Endocrinology and Metabolism·Subhankar Chowdhury
May 23, 2015·Diabetes Care·Kellee M MillerUNKNOWN T1D Exchange Clinic Network
Jul 15, 2015·Pediatric Diabetes·Mark A ClementsUNKNOWN T1D Exchange Clinic Network
Oct 9, 2015·Annals of the New York Academy of Sciences·Tamara S Hannon, Silva A Arslanian
May 15, 2016·Journal of Diabetes Science and Technology·Pradeep A PraveenNikhil Tandon
Mar 1, 2017·JAMA : the Journal of the American Medical Association·Dana DabeleaUNKNOWN SEARCH for Diabetes in Youth Research Group
Apr 14, 2017·The New England Journal of Medicine·Elizabeth J Mayer-DavisUNKNOWN SEARCH for Diabetes in Youth Study

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.