Treatment-related risk factors for inhibitor development in non-severe hemophilia A after 50 cumulative exposure days: A case-control study.

Journal of Thrombosis and Haemostasis : JTH
Amal AbdiINSIGHT Study Group

Abstract

Non-severe hemophilia A patients have a life-long inhibitor risk. Yet, no studies have analyzed risk factors for inhibitor development after 50 factor VIII (FVIII) exposure days (EDs). This case-control study investigated treatment-related risk factors for inhibitor development in non-severe hemophilia A and assessed whether these risk factors were different for early versus late inhibitor development. Non-severe hemophilia A patients (FVIII:C 2%-40%) were selected from the INSIGHT study. Inhibitor-positive patients were defined as early (<50 EDs) or late (>50EDs) cases and matched to 1-4 inhibitor-negative controls by year of birth, cumulative number of EDs, and center/country. We investigated treatment intensity during the last 10 EDs prior to inhibitor development. Intensive treatment was defined as: surgery, peak treatment (10 consecutive EDs), and high mean FVIII dose (>45 IU/kg/ED). Odds ratios (OR) were calculated by logistic regression. Of 2709 patients, we analyzed 63 early and 26 late cases and 195 and 71 respectively matched controls. Peak treatment was associated with early and late inhibitor risk (crude OR 1.8, 95% confidence interval [CI] 1.0-3.4; 4.0, 95%CI 1.1-14.3). This association was slightly less pronounced...Continue Reading

References

Apr 16, 2002·Science·Polly Matzinger
Jun 28, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·J Wight, S Paisley
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·A SharathkumarM D Carcao
Jun 29, 2004·Journal of Thrombosis and Haemostasis : JTH·S C DarbyUNKNOWN UK Haemophilia Centre Doctors' Organisation
Jul 27, 2005·British Journal of Haematology·Elena SantagostinoPier Mannuccio Mannucci
Feb 16, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·S Donadel-Claeyssens, UNKNOWN European Paediatric Network for Haemophilia Management
Aug 10, 2007·The New England Journal of Medicine·Marilyn J Manco-JohnsonBruce L Evatt
Jun 25, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·R d'OironM Jacquemin
Aug 24, 2010·Ageing Research Reviews·Daniela FrascaBonnie B Blomberg
Nov 13, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·P S MacleanUNKNOWN Paediatric Working Party of UKHCDO
Jan 19, 2011·Journal of Clinical Immunology·Christoph R ArnoldBeatrix Grubeck-Loebenstein
Mar 31, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·C LeissingerUNKNOWN HTRS Investigators
Aug 20, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·E P Mauser-BunschotenK Fischer
May 5, 2012·Seminars in Immunology·Janko Nikolich-ŽugichMegan J Smithey
May 9, 2012·Seminars in Immunology·Igor KogutJohn C Cambier
Jun 27, 2012·American Journal of Hematology·Christine L KemptonJ Michael Soucie
Jul 11, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·A SrivastavaUNKNOWN Treatment Guidelines Working Group on Behalf of The World Federation Of Hemophilia
Apr 5, 2013·Blood·Samantha C GouwUNKNOWN PedNet and Research of Determinants of INhibitor development (RODIN) Study Group
Aug 9, 2013·Blood·Corien L EckhardtUNKNOWN INSIGHT Study Group
Jul 26, 2014·Journal of Thrombosis and Haemostasis : JTH·V S BlanchetteA Srivastava
Jan 24, 2015·American Journal of Hematology·Christopher E WalshUNKNOWN United States Hemophilia Treatment Center Network
Feb 27, 2016·BMJ : British Medical Journal·Neil Pearce
May 26, 2016·The New England Journal of Medicine·Flora PeyvandiFrits R Rosendaal
Dec 19, 2016·Haemophilia : the Official Journal of the World Federation of Hemophilia·F PeyvandiM Makris
Jul 6, 2017·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Matteo RotaLorenzo G Mantovani
Mar 20, 2018·Frontiers in Public Health·Chia-Ling KuoJames Grady

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