Treatment-related toxicities in children with acute lymphoblastic leukaemia predisposition syndromes

European Journal of Medical Genetics
Kjeld Schmiegelow

Abstract

Although most children with acute lymphoblastic leukaemia (ALL) do not harbor germline mutations that strongly predispose them to development of this malignancy, large syndrome registries and detailed mapping of exomes or whole genomes of familial leukaemia kindreds have revealed that 3-5% of all childhood ALL cases are due to such germline mutations, but the figure may be higher. Most of these syndromes are primarily characterized by their non-malignant phenotype, whereas ALL may be the dominating or even only striking manifestation of the syndrome in some families. Identification of such ALL patients is important in order to adjust therapy and offer genetic counseling and cancer surveillance to mutation carriers in the family. In the coming years large genomic screening projects are expected to reveal further hitherto unrecognised familial ALL syndromes. The treatment of ALL cases harboring cancer predisposing mutations can be challenging for both the physician and the patient due to their preexisting symptoms, their reduced tolerance to radio- and/or chemotherapy with enhanced risk of life-threatening organ toxicities, and the paucity of data from ALL patients with the same or similar syndromes being treated by contemporary ...Continue Reading

References

Jun 11, 1999·Journal of Pediatric Hematology/oncology·R E GoldsbyC S Bruggers
Mar 4, 2000·Current Opinion in Hematology·T N WilligC A Sieff
Mar 30, 2004·Pediatric Blood & Cancer·Wlodzimierz LuczynskiMaryna Krawczuk-Rybak
Aug 4, 2004·Leukemia Research·Kari Hemminki, Bowang Chen
Apr 13, 2006·Pediatric Blood & Cancer·Parinda A MehtaStella M Davies
May 3, 2007·Blood·James B NachmanGritta E Janka-Schaub
Jul 9, 2009·Human Genetics·Kathrine Damm Meyle, Per Guldberg
Jul 21, 2009·International Journal of Radiation Oncology, Biology, Physics·Julianne M Pollard, Richard A Gatti
Aug 18, 2009·Nature Genetics·Lisa R TreviñoMary V Relling
May 6, 2010·Haematologica·Katharina Wimmer, Christian P Kratz
Nov 16, 2010·Current Opinion in Hematology·Michael H AlbertHans D Ochs
Jan 6, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Anne M HorganGeoffrey Liu
Feb 8, 2011·Pediatric Blood & Cancer·Bendik LundUNKNOWN Nordic Society of Paediatric Haematology and Oncology
Mar 1, 2011·Clinical and Experimental Immunology·G Ram, J Chinen
Apr 19, 2011·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Christian P KratzPhilip S Rosenberg
May 7, 2011·Pediatric Blood & Cancer·Frederick D GoldmanSinisa Dovat
May 25, 2011·Haematologica·Elena Liew, Carolyn Owen
Jan 24, 2012·Nature Structural & Molecular Biology·Hyungjin KimAlan D D'Andrea
Jun 14, 2012·Pediatric Blood & Cancer·Sue RichardsUNKNOWN Childhood Acute Lymphoblastic Leukemia Collaborative Group (CALLCG)
Nov 10, 2012·Leukemia·C BohnstedtUNKNOWN Nordic Society of Pediatric Hematology and Oncology (NOPHO)
Jan 22, 2013·Nature Genetics·Linda HolmfeldtCharles G Mullighan
May 22, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kjeld SchmiegelowMaria Grazia Valsecchi
Nov 16, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Thomas Leth FrandsenKjeld Schmiegelow
Nov 16, 2013·Blood·Shai IzraeliJames Whitlock
Nov 19, 2013·Pediatric Clinics of North America·S Deborah Chirnomas, Gary M Kupfer

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