Treatment resistance of solid tumors: role of hypoxia and anemia

Medical Oncology
P VaupelM Hoeckel

Abstract

Hypoxia is a characteristic property of locally advanced solid tumors, resulting from an imbalance between the supply and consumption of oxygen. Major pathogenetic mechanisms for the development of hypoxia are (1) structural and functional abnormalities of the tumor microvasculature, (2) increased diffusion distances, and (3) tumor-associated and therapy-induced anemia. The oxygenation status is independent of clinical tumor size, stage, grade, and histopathological type, but is affected by the hemoglobin level. Hypoxia is intensified in anemic patients, especially in tumors with low perfusion rates. Hypoxia and anemia (most probably via worsening of tumor hypoxia) can lead to therapeutic problems, as they make solid tumors resistant to sparsely ionizing radiation and some forms of chemotherapy. In addition to more direct mechanisms involved in the development of therapeutic resistance, there are also indirect machineries that can cause barriers to therapies. These include hypoxia-driven proteome and genome changes and clonal selection. These, in turn, can drive subsequent events that are known to further increase resistance to therapy (in addition to critically affecting long-term prognosis). Treatment resistance in anemic pat...Continue Reading

Citations

Dec 24, 2005·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Pilar M Samper OtsJosé M Delgado Pérez
Dec 11, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·C OstheimerD Vordermark
Jul 8, 2009·International Journal of Colorectal Disease·Seong Dae LeeJae Hwan Oh
May 25, 2013·Journal of Gastroenterology·Takeo ToshimaYoshihiko Maehara
Nov 22, 2007·Breast Cancer Research and Treatment·Petra van der GroepPaul J van Diest
Apr 4, 2007·Cancer Metastasis Reviews·D LukashevM Sitkovsky
Apr 19, 2007·Cancer Metastasis Reviews·Peter Vaupel, Arnulf Mayer
Sep 6, 2007·Cancer Metastasis Reviews·Richard J Epstein
Jul 11, 2006·Journal of Mammary Gland Biology and Neoplasia·Yun Shin ChunYuman Fong
May 2, 2009·Pharmaceutical Research·Mei Lan TanTengku Sifzizul Tengku Muhammad
Apr 12, 2008·Purinergic Signalling·Dmitriy LukashevAkio Ohta
Dec 23, 2011·Bulletin of Mathematical Biology·Berta Mendoza-JuezVíctor M Pérez-García
Feb 22, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Hong QiuHuihua Xiong
Apr 14, 2011·Journal of Gastrointestinal Cancer·David KevansJacintha O'Sullivan
Apr 4, 2009·International Journal of Hematology·Marek Z WojtukiewiczSergiusz Nawrocki
May 22, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan YiZhongtang Wang
Oct 11, 2003·Pharmacology & Therapeutics·Stefania MerighiPier Andrea Borea
May 10, 2003·International Journal of Radiation Oncology, Biology, Physics·Philipp BurriGünther Gruber
Mar 26, 2003·International Journal of Radiation Oncology, Biology, Physics·Georg StübenPeter Vaupel
Jun 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Arnulf MayerPeter Vaupel
Nov 23, 2006·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·D A X SchinaglW J G Oyen
Jun 23, 2009·Journal of Clinical Pathology·P van der GroepE van der Wall
Feb 20, 2010·Obstetrics and Gynecology International·Laura M S SeeberPaul J van Diest
Jun 3, 2009·Cancer Research·Robert A GatenbyB Roy Frieden
Oct 19, 2004·Oncology·Eric Pujade-Lauraine, Pere Gascón
Jul 9, 2013·BMC Cancer·Sara StreseJoachim Gullbo
Nov 29, 2007·Annals of Surgical Oncology·Xiong-Zhi Wu
Dec 28, 2011·Oncology Reports·Mitsuhiro ShirakawaYuichiro Doki
Dec 3, 2014·Genomics·Feda' H Hamdan, Malek A Zihlif
Dec 18, 2013·Antioxidants & Redox Signaling·Chen-Ting LeeMark W Dewhirst

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer -Omics

A variety of different high-throughput technologies can be used to identify the complete catalog of changes that characterize the molecular profile of cohorts of tumor samples. Discover the latest insights gained from cancer 'omics' in this feed.

Cancer Metabolism: Therapeutic Targets

Targeting the mechanisms by which cancer cells acquire energy for metabolic needs is a therapeutic target. Discover the latest research on cancer metabolism and therapeutic targets.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.