Treatment-resistant depression

Psychotherapy and Psychosomatics
J Ananth

Abstract

Our ability to treat depression has improved with the availability of receptor-specific and chemically diverse groups of antidepressants. Even now, most of the short-term studies indicate that about 20% of depressed patients remain resistant to treatment. Therefore, it is important to properly assess the treatment-resistant depressed (TRD) patients and to separate the truly refractory patients from those inadequately treated. Undiagnosed medical conditions should be eliminated. TRD is neither a clinically nor a biologically identifiable entity. As there are no established methods for the treatment of TRD, all options should be considered. The clinician can be enriched by the knowledge of the treatment modalities available, and yet, in treating an individual patient, clinical skills, intuitive judgment, family history of response to drugs and side effects, all play a vital role. Several of the approaches described in the paper indicate available methods and their merits in general but there is no way of ascertaining by which particular method a patient should be treated. The three common methods of treatment are substitution of one antidepressant drug for another, combination therapies and augmentation techniques. These are base...Continue Reading

Citations

Jun 28, 2006·Psychopharmacology·Marina SagudNela Pivac
Oct 2, 2013·L'Encéphale·A LedouxL Angeletti
Jan 18, 2014·L'Encéphale·P De MaricourtR Gaillard
Jun 9, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark Hyman RapaportCharles B Nemeroff
Apr 6, 2006·Psychiatry and Clinical Neurosciences·Mutsuhiro Nakao, Eiji Yano
Aug 8, 2009·Psychiatry and Clinical Neurosciences·Ryo Kumagai, Yosuke Ichimiya
Apr 23, 2003·Biological Psychiatry·Andrea Fagiolini, David J Kupfer
Jul 9, 2008·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Cornelius SchüleRainer Rupprecht
Nov 6, 2001·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·G Hasey
Apr 21, 2007·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Marcelo T Berlim, Gustavo Turecki
Apr 4, 2008·Acta Psychiatrica Scandinavica·L F Gram, UNKNOWN Danish University Antidepressant Group (DUAG)
Apr 25, 2007·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Cornelius SchüleRainer Rupprecht
Dec 14, 2019·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Mariam Bonyadi CamachoThomas J Anastasio

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