Treatment response and preliminary efficacy of hepatic tumour laser ablation under the guidance of percutaneous and endoscopic ultrasonography

World Journal of Surgical Oncology
Weilu ChaiTian'an Jiang

Abstract

Studies focusing on the treatment effectiveness of endoscopic ultrasonography (EUS)-guided laser ablation (LA) for hepatic tumours or the technical differences from percutaneous ultrasonography (US)-guided LA are lacking. The objective of this study was to evaluate the treatment response and preliminary efficacy of US- and EUS-guided LA for hepatic tumours. We performed a prospective analysis of treatment response and preliminary efficacy in 92 consecutive patients who underwent US-LA and EUS-LA from January 2015 to June 2017. The primary endpoint was complete tumour ablation (CTA). The secondary endpoint was 12-month local tumour progression (LTP). Among a total of 120 hepatic lesions, 20 lesions were ablated under the guidance of EUS. The application of the multi-fibre technique (0, 0% vs. 69, 69.0%, p < 0.01), tumours located in the left lobe (18, 90.0% vs. 28, 28.0%, p < 0.01) and multi-session ablation (4, 20.0% vs. 4, 4.0%, p = 0.009) were factors found to be significantly different between the EUS-LA and US-LA groups. The CTA was achieved in 94% of patients in the US-LA group and 100% of patients in the EUS-LA group (p = 0.261). Twelve-month LTP was observed in 8.5% of the patients in the US-LA group and 15.0% of the pat...Continue Reading

References

Jan 16, 2008·Radiology·Vincenzo ArientiFrancesca Marta Lilja Di Lascio
Oct 30, 2010·Gastrointestinal Endoscopy·Francesco Di MatteoGuido Costamagna
May 29, 2012·Gastrointestinal Endoscopy Clinics of North America·Won Jae Yoon, William R Brugge
Jun 14, 2013·Acta Radiologica·Giovan Giuseppe Di CostanzoClaudio Maurizio Pacella
Jun 27, 2013·World Journal of Gastroenterology : WJG·Wen-Ying ZhangZhen-Dong Jin
Sep 25, 2014·Journal of Gastroenterology and Hepatology·Giovan Giuseppe Di CostanzoClaudio Maurizio Pacella
Oct 18, 2014·Clinical Endoscopy·Ji Young Bang, Shyam Varadarajulu

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Citations

Apr 18, 2020·Journal of Medical Ultrasonics·Shuya MaeshimaMasayuki Kitano

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Methods Mentioned

BETA
sedation

Clinical Trials Mentioned

NCT02816944

Software Mentioned

SPSS

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