Treatment response in COPD: does FEV1 say it all? A post hoc analysis of the CRYSTAL study

ERJ Open Research
Konstantinos KostikasClaus F Vogelmeier

Abstract

The association between clinically relevant changes in patient-reported outcomes (PROs) and forced expiratory volume in 1 s (FEV1) in patients with chronic obstructive pulmonary disease (COPD) has rarely been investigated. Using CRYSTAL, a 12-week open-label study in symptomatic, nonfrequently exacerbating patients with moderate COPD, we assessed at baseline the correlations between several PROs (Baseline Dyspnoea Index, modified Medical Research Council dyspnoea scale, COPD Assessment Test (CAT) and Clinical COPD Questionnaire (CCQ)), and between FEV1 and PROs. Associations between clinically relevant responses in FEV1, CAT, CCQ and Transition Dyspnoea Index (TDI) at week 12 were also assessed. Using data from 4324 patients, a strong correlation was observed between CAT and CCQ (rs=0.793) at baseline, with moderate or weak correlations between other PROs, and no correlation between FEV1 and any PRO. At week 12, 2774 (64.2%) patients were responders regarding TDI, CAT or CCQ, with 583 (13.5%) responding using all three measures. In comparison, 3235 (74.8%) were responders regarding FEV1, TDI, CAT or CCQ, with 307 (7.1%) responding concerning all four parameters. Increases in lung function were accompanied by clinically relevant...Continue Reading

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Citations

Dec 10, 2019·American Journal of Respiratory and Critical Care Medicine·Hana MüllerováRuth Tal-Singer
Jun 4, 2020·Respiratory Research·Dave SinghMeiLan K Han
Aug 18, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Nuzhat AfrozKonstantinos Kostikas
May 13, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Claus F VogelmeierIsabelle H Boucot
Jun 10, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Hyun-Il GilSun Hye Shin
Mar 23, 2021·American Journal of Respiratory and Critical Care Medicine·Courtney CrimJames F Donohue
Aug 3, 2021·Journal of Pharmaceutical Health Care and Sciences·Eiji ShiwakuYuka Kobayashi
Aug 21, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Dave SinghFernando J Martinez

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Clinical Trials Mentioned

NCT01985334

Software Mentioned

CAT
CRYSTAL

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