Treatment response in major depression: effects of personality dysfunction and prior depression

The British Journal of Psychiatry : the Journal of Mental Science
Philip GorwoodPaul Moran

Abstract

The impact of personality dysfunction on the outcome of treatment for depression remains debated. To examine the relationship between the number of prior depressive episodes, personality dysfunction and treatment response for depression. In a large sample (n = 8229) of adult out-patients with a major depressive episode (DSM-IV), personality dysfunction was assessed using the Standardised Assessment of Personality - Abbreviated Scale (SAPAS). Potential predictors of treatment response at 6 weeks were examined via structural equation modelling. The amount of personality dysfunction and number of prior episodes of depression were both associated with poor response to treatment. Once personality dysfunction was controlled for, the number of prior episodes of depression was not associated with treatment response. Personality dysfunction is associated with impaired short-term response to antidepressant treatment in major depression. The apparent detrimental effect of prior depression on treatment response may be accounted for by pre-existing personality dysfunction.

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Citations

May 30, 2013·PloS One·Michio TakahashiKenji Hashimoto
Jun 22, 2013·Journal of Personality Disorders·Jeffrey R VittenglRobin B Jarrett
Jun 26, 2013·Journal of Personality Disorders·Marcella FokPaul Moran
Feb 23, 2011·International Review of Psychiatry·Zoë FortunePaul Moran
Mar 1, 2012·The Psychiatric Clinics of North America·Gabor I Keitner, Abigail K Mansfield
Oct 24, 2015·The British Journal of Psychiatry : the Journal of Mental Science·Andrea Du PreezCarmine M Pariante
Jan 5, 2013·Depression and Anxiety·Felipe A JainAndrew F Leuchter
Jun 3, 2011·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Peter Tyrer
Sep 1, 2015·Personality and Mental Health·Marcella Lei-Yee FokPaul Moran
Aug 1, 2015·Behaviour Research and Therapy·Elizabeth GoddardPaul Moran
Dec 20, 2011·Journal of the American Academy of Child and Adolescent Psychiatry·Susan ConroyPaul Moran
Jul 9, 2016·Journal of Personality Disorders·Laura BallVincent Egan
Mar 21, 2017·Frontiers in Psychology·Francesca StraccamoreOsmano Oasi
Mar 22, 2012·The International Journal of Social Psychiatry·Helen TyrerBarbara Barrett
Feb 26, 2019·BMJ : British Medical Journal·Sara L JohansenNatalie L Rasgon
Aug 14, 2020·Depression and Anxiety·Dana Shamai-LeshemYair Bar-Haim
Nov 29, 2012·Menopause : the Journal of the North American Menopause Society·Quentin R Regestein
Aug 26, 2017·Depression Research and Treatment·Jenifer A MurphyGerard J Byrne
Mar 7, 2021·Journal of Personalized Medicine·Angelos HalarisElizabeth A Whitham
Jun 18, 2021·American Journal of Psychotherapy·Suzanne C van BronswijkFrenk P M L Peeters
Aug 24, 2021·Neuropsychiatric Disease and Treatment·Alina WilkowskaWiesław J Cubała

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