PMID: 15222692Jun 30, 2004Paper

Treatment response in relation to inflammatory and axonal surrogate marker in multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
A PetzoldM Clanet

Abstract

This study aimed to investigate if treatment response could retrospectively be related to inflammatory or axonal pathology as measured by plasma surrogate markers. In this 1-year observational study 30 multiple sclerosis (MS) patients with relapsing-remitting disease were treated with intramuscular IFNbeta-1a or subcutaneous IFNbeta-1b. Responders and nonresponders were defined according to clinical and magnetic resonance imaging criteria. The control group consisted of 14 healthy subjects. Plasma levels of surrogate markers for inflammation (nitric oxide metabolites (NOx)), astrocytic activation (S100B) and axonal damage (NfH(SM135)) were measured using standard assays. There were 11 nonresponders and 19 responders to IFNbeta treatment. Median S100B levels were elevated in a higher proportion of treatment responders (63%, 42.9 pg/mL) compared to nonresponders (18%, 11.7 pg/mL, P < 0.05, Fisher's exact test) and controls (0%, 2 pg/mL, P < 0.001). Levels of NOx were found to be more frequently elevated in nonresponders (72%, 39 microM) compared to healthy controls (0%, 37 microM, P < 0.05). Levels of NfH(SM135) were more frequently elevated in responders (58%, 300 pg/mL, P < 0.001) and nonresponders (72%, 500 pg/mL, P < 0.001) c...Continue Reading

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Citations

Oct 2, 2009·Nature Reviews. Neurology·Jordi RíoXavier Montalban
Nov 19, 2011·Multiple Sclerosis International·Barbara TavazziGiuseppe Lazzarino
Nov 19, 2011·Multiple Sclerosis International·Irena Dujmovic
Nov 19, 2011·Multiple Sclerosis International·M J EikelenboomA Petzold
Mar 13, 2012·The FEBS Journal·Aye M Myint
May 17, 2008·CNS Neuroscience & Therapeutics·Jop P MostertJacques De Keyser
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Nov 22, 2012·Clinical and Experimental Pharmacology & Physiology·Ryusuke TakechiJohn C Mamo
Dec 17, 2015·Journal of Neuroinflammation·L SchreweA Chan
May 30, 2019·Annals of Clinical and Translational Neurology·Basil T DarrasCharlotte J Sumner
Jan 27, 2006·Annals of Neurology·Jordi RíoXavier Montalban
Oct 10, 2012·The Pharmacogenomics Journal·V Foti CuzzolaS Marino
Mar 6, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Gavin Giovannoni
Mar 30, 2011·FEBS Letters·Djordje MiljkovićMarija Mostarica Stojković
Nov 14, 2008·Expert Opinion on Pharmacotherapy·Iván Martinez-ForeroPablo Villoslada
Aug 25, 2012·Multiple Sclerosis : Clinical and Laboratory Research·M KhalilC E Teunissen
Jul 31, 2018·Brain : a Journal of Neurology·Gavin Giovannoni
May 18, 2005·Journal of the Neurological Sciences·Axel Petzold
Jun 29, 2007·Journal of Translational Medicine·Thomas E IchimNeil H Riordan

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