Treatment results and prognostic factors for advanced squamous cell carcinoma of the head and neck treated with salvage surgery after concurrent chemoradiotherapy

International Journal of Clinical Oncology
Takahide TaguchiNobuhiko Oridate

Abstract

For primary organ preservation, concurrent chemoradiotherapy (CCRT) is performed for advanced squamous cell carcinoma of the head and neck (SCCHN). In this organ-preservation setting with CCRT, surgery is reserved as a salvage treatment in cases of locoregional failure after CCRT. The purpose of the study was to review our experience with salvage surgery after CCRT for patients with SCCHN and to evaluate the effectiveness and prognostic factors affecting survival. The records of patients with stage II-IVB SCC of the larynx, oropharynx, or hypopharynx treated with salvage surgery after CCRT between 1998 and 2012 were reviewed. A total of 645 patients with previously untreated, resectable SCC of the larynx, oropharynx, or hypopharynx received CCRT. Salvage surgery was performed for 78 of 225 patients with residual or recurrent tumors. The 5-year overall survival (OS) and disease-specific survival rates for patients who received salvage surgery were 61.0 and 65.5 %, respectively. Stage IV, poorly differentiated, synchronous double cancer, and surgical complications were significant predictors of unfavorable OS on multivariate analysis. Postoperative complications were observed in 30 patients (38.5 %). Salvage surgery is the best t...Continue Reading

References

Nov 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A FortinB Tetu
Jan 15, 2003·Archives of Otolaryngology--head & Neck Surgery·Randal S WeberJohn Ensley
Dec 6, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fabrice DenisGilles Calais
Jan 11, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Luke M RicheyMark C Weissler
Sep 12, 2008·The New England Journal of Medicine·Jan B VermorkenRicardo Hitt
Dec 19, 2008·International Journal of Clinical Oncology·Yasushi FurutaSatoshi Fukuda
May 25, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Shigenari TakiSatoshi Fukuda
Jun 10, 2010·The New England Journal of Medicine·K Kian AngMaura L Gillison
Aug 20, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·E EstellerX León
Jul 26, 2012·International Journal of Clinical Oncology·Satoshi KanoMasato Fujii
Nov 28, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arlene A ForastiereJay S Cooper
Sep 14, 2013·Japanese Journal of Clinical Oncology·Kensuke SuzukiSatoshi Fujii
Jun 25, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carole FakhryMaura Gillison

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Citations

Jun 22, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Pei-Hsin ChuTuan-Jen Fang
Dec 18, 2019·Japanese Journal of Clinical Oncology·Takashi MaruoRyuichi Hayashi
Feb 12, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Philippe GorpheFrançois Janot
Mar 21, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Molly E Heft NealMatthew E Spector
Nov 8, 2020·Head & Neck·Johannes DoescherStephanie Ellen Weissinger
Dec 4, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Roel HennemanAlfons Jm Balm

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