Treatment results in advanced stage Hodgkin's lymphoma: a retrospective study

Journal of Postgraduate Medicine
H JainEpari Sridhar

Abstract

Hodgkin's lymphoma displays distinct epidemiological attributes in Asian population thus making it relevant to study whether there are any differences in treatment outcomes too when treated with current standard of care. To evaluate the treatment outcomes of de-novo advanced stage HL in adults. This retrospective study included de-novo advanced stage HL patients (≥15 years) registered at our center from January 2004 to December 2007. Treatment outcomes were measured in terms of response rates, overall survival (OS) and progression-free survival (PFS). Overall and PFS were calculated with Kaplan-Meier methodology and Cox-proportional hazards model was used for multivariate analysis to identify prognostic factors. There were 125 patients (males 77%) who received minimum one cycle of chemotherapy with median age of 32 years (Range 15-65 years). Stage IV disease was seen in (46 patients) 37%; 75% (94 patients) patients had B symptoms. International prognostic score (IPS) ≤4 was seen in 95/112 (85%) patients. ABVD (adriamycin, bleomycin, vinblastine, dacarbazine) chemotherapy was given to 94%. Radiation to residual/bulky sites was given to 36% (45 patients). Response data was available for 112 patients; complete response in 76%; par...Continue Reading

Citations

Apr 5, 2016·Hematology/oncology Clinics of North America·Reena DasMan Updesh Singh Sachdeva
Dec 14, 2019·Journal of Global Oncology·Arun SeshachalamHemant Deepak Shewade
Aug 22, 2018·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Reena NairVivek Radhakrishnan
Oct 23, 2020·Journal of Adolescent and Young Adult Oncology·Lingaraj NayakManju Sengar

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