Treatment results of chemoradiotherapy for clinical stage I (T1N0M0) esophageal carcinoma

International Journal of Radiation Oncology, Biology, Physics
Kazunari YamadaSatoru Matsusue

Abstract

In 1991, we started a clinical prospective trial for operable esophageal carcinoma, foreseeing organ preservation, to assess the treatment results after definitive chemoradiotherapy (CRT) for clinical Stage I (T1N0M0) esophageal cancer. Between 1992 and 2003, 63 patients were enrolled in this study. Tumor depth was mucosal cancer (T1a) in 23 and submucosal cancer (T1b) in 40. CRT consisted of 55-66 Gy/50-60 fractions (median, 59.4 Gy); from 1 to 3 cycles (median, 2) of concurrent chemotherapy (Cisplatin and 5-fluorouracil), followed by high-dose-rate intraluminal brachytherapy 10-12 Gy/2-3 fractions. The 5-year overall and cause-specific and disease-free survival rates were 66.4%, 76.3%, and 63.7%, respectively. The 5-year cause-specific survival rates for T1a and T1b cancer patients were 85.2% and 70.0%, respectively (p = 0.06). The 5-year disease-free survival rates for T1a and T1b were 84.4% and 50.5%, respectively (p < 0.01). Esophageal fistula as a late toxicity occurred in 2 patients (G4: 1; G5: 1), and esophageal stricture requiring a liquid diet occurred in 2 patients. Pericardial effusion was observed in 3 patients. We confirmed that patients with T1N0M0 esophageal carcinoma had their esophagus preserved in 89.2% of ca...Continue Reading

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Citations

Aug 26, 2009·International Journal of Clinical Oncology·Kiyoaki Tsukahara, Kazuyoshi Kawabata
Sep 4, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Donald E LowRichard A Kozarek
May 19, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Donald E Low
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Jun 15, 2011·Japanese Journal of Clinical Oncology·Yoshifumi KawaguchiSatoaki Nakamura
Oct 9, 2007·American Journal of Clinical Oncology·Tomonari SasakiHiroshi Honda
Nov 5, 2010·The Journal of Thoracic and Cardiovascular Surgery·Madhankumar KuppusamyDonald E Low
Feb 16, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Takeshi KodairaAkinori Takada
Oct 31, 2009·Brachytherapy·Maria Grazia FabriniLuca Cionini
Mar 25, 2015·International Journal of Clinical Oncology·Yuji MurakamiYasushi Nagata
Apr 22, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Á RovirosaS Rodríguez
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Dec 6, 2019·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Waku HattaAtsushi Masamune
Sep 2, 2018·Esophagus : Official Journal of the Japan Esophageal Society·Yuko KitagawaMasahiro Yoshida
Sep 2, 2018·Esophagus : Official Journal of the Japan Esophageal Society·Yuko KitagawaMasahiro Yoshida
Feb 25, 2021·Esophagus : Official Journal of the Japan Esophageal Society·Kazuhiko MoriYasuyuki Seto

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