PMID: 3756355Oct 1, 1986Paper

Treatment results of nine patients with Burkitt's lymphoma

Blut
B AngerH Heimpel

Abstract

From 6/79 until 2/86, 9 patients (median age 39) with Burkitt's lymphoma were treated. Stage D disease was seen in 7 cases, stage C in two and stage A in one. The main symptom was abdominal pain or a rapidly progressing abdominal tumor. Three patients had bone marrow involvement and two had a Burkitt's leukemia. Three had typical chromosomal aberrations. Therapy consisted of a variety of chemotherapy regimens plus additional radiotherapy and/or bulk surgery. Two patients achieved complete remissions (of 6 and 20+ months duration), and 4 partial remissions were obtained. The remaining patients had either progressive, drug resistant disease or died early. One patient is currently alive and in complete remission at 20+ months. A second patient is alive at 20+ months in partial remission with traces of IgM-paraprotein still detectable. The main causes of death were tumor-lysis syndrome (4 patients) and therapy related sepsis with progressive tumor (3 patients). This poor outcome is probably due to a high proportion of high-risk patients and suboptimal therapy for this rapidly proliferating tumor.

References

Dec 25, 1975·The New England Journal of Medicine·G Klein
May 16, 1985·Nature·G Klein, E Klein
Nov 1, 1982·Cancer Genetics and Cytogenetics·R Berger, A Bernheim
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R Dalla-FaveraC M Croce
Sep 24, 1981·The New England Journal of Medicine·J L Ziegler
Feb 15, 1982·International Journal of Cancer. Journal International Du Cancer·S ZhangG Klein
Apr 1, 1980·The American Journal of Medicine·L F CohenJ L Ziegler

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