Treatment results of post-operative radiotherapy in patients with salivary duct carcinoma of the major salivary glands.

The British Journal of Radiology
J Y KimS D Ahn

Abstract

Salivary duct carcinoma (SDC) is a rare malignancy of high-grade pathological type. We evaluated clinical outcomes and prognostic factors in 35 patients with SDC treated post-operatively with adjuvant radiation. We retrospectively assessed overall survival, locoregional control and disease-free survival in 35 patients with SDC of the major salivary glands who underwent surgery and were subsequently treated with radiotherapy. The evaluated prognostic factors included gender, age, symptom duration, tumour site, tumour size, TNM classification, and the following pathological features: perineural invasion, lymphovascular invasion, extraparenchymal invasion and resection-margin status. Of the 35 patients, 30 (85.7%) were male. Median age at initial diagnosis was 62 years (range 38-75 years). The parotid gland was the main site affected in 22 patients (62.9%). 18 patients (51.5%) had pathological T3/T4 tumours, and 26 (74.3%) showed pathological nodal involvement. Actuarial 5-year locoregional control, disease-free survival and overall survival rates were 63.3%, 47.4% and 55.1%, respectively. The cause-specific death rate was 31.4% (n=11). Pathological nodal involvement was correlated with distant metastasis (p=0.011). Lymphovascular...Continue Reading

References

Mar 1, 1991·Archives of Otolaryngology--head & Neck Surgery·W J KaneJ E Lewis
Jun 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I W DimeryW K Hong
Jan 1, 1987·Head & Neck Surgery·L E AfzeliusC Svensson
Jan 1, 1968·Archiv für klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde·C M EnerothJ Wersäll
Sep 1, 1993·Cancer·R DelgadoJ Albores-Saavedra
Mar 1, 1995·Histopathology·R T GrenkoB Boeryd
Jun 1, 1993·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·C Colmenero RuizM Martín Pérez
Dec 10, 2003·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·A Sefik HosalEugene N Myers
Apr 15, 2008·The Journal of Laryngology and Otology·M Nashed, R J Casasola
Dec 31, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Young Hyeh KoHan-Sin Jeong

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Citations

Sep 12, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Shuang ShiChangfu Sun
Jul 15, 2015·Oncology Letters·Xiaofeng HuangRunzhi Deng
Jan 30, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Helle BreinholtKristine Bjørndal
Apr 29, 2015·Head & Neck·Meredith L JohnstonJohn Kim
Feb 24, 2015·The Journal of Laryngology and Otology·T NakashimaS Komune
May 18, 2016·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Khalid Hussain Al-QahtaniHanadi Fatani
Nov 8, 2014·The Journal of Craniofacial Surgery·Shuang ShiChangfu Sun
Mar 17, 2016·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Matthew MifsudJimmy Caudell
Aug 23, 2017·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Marlen HaderleinAbbas Agaimy
Oct 18, 2014·Radiation Oncology Journal·Tae Hyung KimKi Chang Keum
Sep 5, 2019·Clinical and Experimental Otorhinolaryngology·Yong-Hyub KimSang Chul Lim
Jun 8, 2017·Molecular and Clinical Oncology·Kenta KawaharaHideki Nakayama
Mar 12, 2021·Frontiers in Oncology·Takayoshi SuzukiAkihiro Homma
Apr 27, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jessica L GeigerPatrick Ha

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