Treatment strategies for combining immunostimulatory oncolytic virus therapeutics with dendritic cell injections

Mathematical Biosciences and Engineering : MBE
Joanna R WaresPeter S Kim

Abstract

Oncolytic viruses (OVs) are used to treat cancer, as they selectively replicate inside of and lyse tumor cells. The efficacy of this process is limited and new OVs are being designed to mediate tumor cell release of cytokines and co-stimulatory molecules, which attract cytotoxic T cells to target tumor cells, thus increasing the tumor-killing effects of OVs. To further promote treatment efficacy, OVs can be combined with other treatments, such as was done by Huang et al., who showed that combining OV injections with dendritic cell (DC) injections was a more effective treatment than either treatment alone. To further investigate this combination, we built a mathematical model consisting of a system of ordinary differential equations and fit the model to the hierarchical data provided from Huang et al. We used the model to determine the effect of varying doses of OV and DC injections and to test alternative treatment strategies. We found that the DC dose given in Huang et al. was near a bifurcation point and that a slightly larger dose could cause complete eradication of the tumor. Further, the model results suggest that it is more effective to treat a tumor with immunostimulatory oncolytic viruses first and then follow-up with a...Continue Reading

References

Feb 23, 2000·Journal of Virology·I GanlyA Balmain
Mar 23, 2001·Nature Immunology·H Veiga-FernandesB Rocha
Oct 25, 2003·Journal of Theoretical Biology·T AlarcónP K Maini
Jun 24, 2004·Bulletin of Mathematical Biology·Joseph T WuLawrence M Wein
Sep 20, 2005·Journal of Theoretical Biology·D G Mallet, L G De Pillis
Aug 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michele Del VecchioAndrea Anichini
Mar 5, 2008·Journal of Theoretical Biology·Zeljko BajzerDavid Dingli
Mar 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wilson MokRakesh K Jain
Sep 10, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jing-Hua HuangChae-Ok Yun
Sep 30, 2009·Bulletin of Mathematical Biology·Matt BieseckerZeljko Bajzer
Jan 21, 2010·Journal of Theoretical Biology·Natalia L Komarova, Dominik Wodarz
Mar 13, 2010·Bulletin of Mathematical Biology·Raluca EftimieDavid J D Earn
Mar 18, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Fabrice Le BoeufJohn C Bell
Mar 26, 2011·Cancer Gene Therapy·R M Eager, J Nemunaitis
Apr 21, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Alan MelcherJohn C Bell
Nov 5, 2011·Journal of Theoretical Biology·Mark Robertson-TessiAlain Goriely
Jun 21, 2012·Pathology Oncology Research : POR·Md ZeyaullahArif Ali
Jul 12, 2012·Nature Biotechnology·Stephen J RussellJohn C Bell
Oct 24, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James R TysomeYaohe Wang
Mar 22, 2013·Frontiers in Oncology·Lisette DepillisAmi Radunskaya
Jun 5, 2013·Neoplasia : an International Journal for Oncology Research·Wei ZhangRobert L Martuza
Jun 15, 2013·Nature Communications·Fabrice Le BœufJohn C Bell
Aug 3, 2013·Mathematical Biosciences and Engineering : MBE·Dominik Wodarz
Oct 16, 2013·Expert Review of Vaccines·Noura B Elsedawy, Stephen J Russell
Dec 3, 2013·Nature Reviews. Microbiology·Tanner S Miest, Roberto Cattaneo
Mar 8, 2014·Bioinformatics·Francesco PappalardoMatteo Bellone

❮ Previous
Next ❯

Citations

Oct 21, 2016·Bulletin of Mathematical Biology·Raluca EftimieDoreen A Cantrell
Aug 24, 2017·Viruses·Daniel N SantiagoHeiko Enderling
Mar 25, 2019·Expert Opinion on Biological Therapy·Victor Cervera-CarrasconAkseli Hemminki
May 16, 2019·Bulletin of Mathematical Biology·Jiantao Zhao, Jianjun Paul Tian
Dec 5, 2018·Computational and Mathematical Methods in Medicine·Jana L Gevertz, Joanna R Wares
Jul 19, 2017·Proceedings of the National Academy of Sciences of the United States of America·Syndi BarishJana L Gevertz
Nov 24, 2016·Mathematical Biosciences and Engineering : MBE·Urszula LedzewiczEddy Pasquier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

BioHub - Researcher Network

The Chan-Zuckerberg Biohub aims to support the fundamental research and develop the technologies that will enable physicians to cure, prevent, or manage all diseases in our childrens' lifetimes. The CZ Biohub brings together researchers from UC Berkeley, Stanford, and UCSF. Find the latest research from the CZ Biohub researcher network here.