Abstract
Treatment strategies for patients with severe aplastic anemia (SAA), depend on the severity of the disease, the age of the patient and the availability of a family donor. Progress in the past has included the early use of combined immunosuppressive therapy (IST) and better matching strategies to select unrelated donors. Currently, the actuarial 10-year survival in 2479 patients registered within the European Group for Blood and Marrow Transplantation (EBMT), is 73 and 68% for patients receiving first-line BMT or IST. The outcome of BMT has significantly improved since 1996, and this is true for both matched sibling donor BMT as well as for alternative donor BMT. Survival is significantly better in children (<16 years) as compared with adults (79 vs 68%, P<0.0001). In contrast, there has been no significant improvement over time for patients receiving IST. Again, results were significantly better in children compared with adults (81 versus 70%, P=0.001), especially in very severe aplasia (83 versus 62%, P=0.0002). This report outlines some of these results as a basis for treatment strategies in SAA.
References
Mar 27, 1976·Lancet·J AscensãoR Good
Jan 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J Y PiergaJ M Cosset
Oct 1, 1993·British Journal of Haematology·H SchrezenmeierW Hinterberger
Jan 15, 1997·Annals of Internal Medicine·N S Young
Feb 27, 1999·Annals of Internal Medicine·A TichelliA Bacigalupo
Dec 3, 1999·British Journal of Haematology·E Di BonaV De Rossi
Feb 17, 2000·Seminars in Hematology·A BacigalupoH Schrezenmeier
May 15, 2001·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·H J DeegB Mueller
Jul 20, 2002·Blood·Seiji KojimaYoshihisa Kodera
Dec 11, 2002·British Journal of Haematology·Eliane GluckmanUNKNOWN European Group for Blood and Marrow Transplantation Working Party for Severe Aplastic Anemia
Oct 28, 2003·Bone Marrow Transplantation·F L DulleyC A De Souza
Dec 5, 2003·Transfusion Medicine·J C W Marsh, M O Elebute
Jun 21, 2005·Experimental Hematology·Andrea BacigalupoGiovanna Piaggio
Oct 6, 2005·Bone Marrow Transplantation·A BacigalupoUNKNOWN Severe Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation
Dec 19, 2006·Bone Marrow Transplantation·S McCannM Lawler
Citations
Apr 1, 1963·The American Journal of Medicine·E R MOVITTW R PORTER
Jul 6, 2012·The New England Journal of Medicine·Donald Metcalf
Jan 5, 2011·Acta Haematologica·Sunday OcheniUlrike Bacher
May 5, 2011·PloS One·Frank PeinemannStefan Lange
Aug 4, 2009·Haematologica·Frank PeinemannStefan Lange
Sep 21, 2010·Haematologica·Vikas GuptaJudith C W Marsh
Dec 20, 2011·Haematologica·Johanna KonopackiRégis Peffault de Latour
Apr 17, 2010·Drugs·A Osama GaberMohamad Mohty
Mar 10, 2012·Journal of Cancer Research and Clinical Oncology·Chun ChenShao-Liang Huang
Jul 24, 2012·Advanced Drug Delivery Reviews·Miroslaw JanowskiPiotr Walczak
Aug 30, 2011·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Bela BalintMilica Cucuz-Jokic
Aug 26, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Hazzaa Al-ZahraniMahmoud Aljurf
Dec 18, 2016·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Hanaa S E MousaAisha A El-Khodary
Jul 25, 2013·The Cochrane Database of Systematic Reviews·Frank PeinemannUlrich Grouven
Jan 25, 2013·Radiation Oncology Journal·Yun-Hee LeeSu-Mi Chung
Sep 25, 2020·Journal of Pediatric Hematology/oncology·Fuxing LiXiaotian Xie