Treatment strategies for persistent methicillin-resistant Staphylococcus aureus bacteraemia

Journal of Clinical Pharmacy and Therapeutics
Paul O LewisDavid B Cluck

Abstract

Treatment of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia is a long-standing challenge to health care, often complicated by metastatic infections, treatment failure and mortality. When MRSA bacteraemia persists despite adequate initial treatment, current Infectious Diseases Society of America guidelines recommend evaluation and removal of possible sources of infection. In addition, a change in therapy may be considered. The objective of this review was to explore the therapeutic options for the treatment of persistent MRSA bacteraemia. A literature search of PubMed, MEDLINE and Google Scholar was performed using the following search terms: [methicillin-resistant Staphylococcus aureus OR MRSA] AND [bacteraemia OR bloodstream infection] AND [persistent OR persistence OR refractory OR treatment failure OR salvage] AND treatment. We evaluated relevant, adult, English-language, peer-reviewed studies published between 1985 and May 2018. In vitro and animal studies were considered as supportive of in vivo data. Randomized, controlled trials are lacking. However, case series and case reports support multiple treatment options including high-dose daptomycin in combination with an antistaphylococcal β-lactam, ceftarolin...Continue Reading

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Citations

Feb 2, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Yingzi HuangHua Shao
Apr 18, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ioannis M Zacharioudakis, Fainareti N Zervou
Dec 5, 2018·Expert Review of Clinical Pharmacology·Giovanni Di PerriStefano Bonora
May 21, 2020·Surgical Infections·Paul M RobbenRoseanne A Ressner
Apr 14, 2020·Photodiagnosis and Photodynamic Therapy·Camilo Geraldo de Souza TeixeiraAna Cláudia Pavarina
Aug 17, 2021·Journal of Pharmacy Practice·Bryan P WhiteDaniel B Chastain

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