Treatment strategies for primary early-stage sinonasal adenocarcinoma: A retrospective bi-institutional case-control study

Journal of Surgical Oncology
Mario Turri-ZanoniPaolo Castelnuovo

Abstract

To investigate different treatment strategies for primary early-stage (pT1-T2) sinonasal adenocarcinomas. Retrospective case-control study. From 2000 to 2011, 61 cases were radically resected using an endoscopic endonasal approach. Surgery as a single treatment modality was adopted for 33 patients (study group) while it was followed by postoperative radiotherapy (poRT) in 28 patients (control group). Median follow-up was 61 and 67 months for the study and control group respectively. Patients were stratified according to the pT classification and no statistically significant differences were found in terms of Overall (OS) and Recurrence-free (RFS) survival. When analyzing the high-grade tumors (47 cases), statistically significant differences were observed between the control and study groups both in terms of OS (90.5% ± 6.5% versus 57.6% ± 15.4%, P = 0.03) and RFS (92.3% ± 7.39% versus 80.2% ± 8.88%, P = 0.05). Using multivariate analysis, OS was independently determined by poRT (Hazard Ratio = 0.16; P = 0.03) thus confirming its protective role for high-grade adenocarcinomas. Our preliminary results suggest that endoscopic endonasal surgery could be used as a single treatment modality for primary early-stage low-grade sinonasa...Continue Reading

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Citations

Jul 2, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Geoffrey MortuaireAnne-Sophie Thisse
Dec 6, 2017·Acta Oto-laryngologica·Suat KılıçJean Anderson Eloy
Sep 6, 2017·Advances in Therapy·Fernando LópezAlfio Ferlito
Feb 2, 2018·Current Opinion in Otolaryngology & Head and Neck Surgery·Vittorio RampinelliPiero Nicolai
Jan 4, 2020·Journal of Neuro-oncology·Marco FerrariPiero Nicolai
Jan 1, 2021·Journal of Neurological Surgery. Part B, Skull Base·Neil N PatelJason A Brant
May 21, 2021·International Forum of Allergy & Rhinology·Khalil IssaRalph Abi Hachem
Aug 6, 2021·Laryngo- rhino- otologie·Fabian Sommer

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