Treatment Switch Patterns and Healthcare Costs in Biologic-Naive Patients with Psoriatic Arthritis.

Advances in Therapy
Jashin J WuJeffrey R Curtis

Abstract

We compared treatment switch patterns and healthcare costs among biologic-naive patients with psoriatic arthritis (PsA) who initiated apremilast or biologics. A 1:2 propensity score match was used to adjust administrative claims data for adults initiating apremilast or biologics from January 1, 2014, to September 30, 2016, for possible selection bias. Patients had at least 12 months of pre- and post-index continuous enrollment in the Optum Clinformatics™ Data Mart database. Outcomes included switch frequency, days to switch, adherence on index treatment, and healthcare costs (total and per patient per month). Switch rate was defined as the proportion of patients who switched to a new treatment after initiation of the index treatment, and days to switch was calculated as the days between initiation of the index treatment and initiation of the new treatment. Adherence was calculated using the proportion of days covered and the medication possession ratio. The t test and chi-square, Kaplan-Meier, and Wilcoxon rank-sum tests were used to evaluate differences between the cohorts. Patient characteristics and switch rates were similar between the matched apremilast (n = 170) and biologic (n = 327) cohorts. After matching, patient char...Continue Reading

References

Apr 2, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Harvey J ClewellJustin G Teeguarden
Jun 5, 2013·Seminars in Arthritis and Rheumatism·Lazaros I SakkasMarianna Vlychou
Oct 15, 2013·Statistics in Medicine·Peter C Austin
Apr 3, 2014·The Journal of Rheumatology·Emily McDonoughDafna D Gladman
Jul 17, 2014·The Journal of Rheumatology·Jessica A WalshDaniel O Clegg
Jan 20, 2015·Drugs in Context·Judy Cheng, Steven R Feldman
Jan 21, 2015·Current Opinion in Rheumatology·Alexis OgdieM Elaine Husni
Jun 16, 2016·BMC Musculoskeletal Disorders·Jacqueline B PalmerZafer E Ozturk
Jun 19, 2016·Actas dermo-sifiliográficas·R Burgos-PolM Á Casado
Jul 9, 2016·Seminars in Arthritis and Rheumatism·Laura C CoatesCarle Paul
Nov 16, 2016·Journal of Cutaneous Medicine and Surgery·Julia N Mayba, Melinda J Gooderham
Mar 9, 2017·The New England Journal of Medicine·Christopher T RitchlinDafna D Gladman
Apr 2, 2017·Seminars in Arthritis and Rheumatism·Joseph F MerolaElinor A Mody
Feb 15, 2018·PharmacoEconomics·Lucia Sara D'AngiolellaLorenzo Giovanni Mantovani
Jul 28, 2018·Clinical Rheumatology·Joseph F MerolaJacqueline B Palmer
Nov 6, 2018·Journal of Comparative Effectiveness Research·Steven R FeldmanMachaon M Bonafede
Feb 18, 2019·Journal of the American Academy of Dermatology·Alan MenterCraig A Elmets
Mar 27, 2019·Journal of Comparative Effectiveness Research·Kurt R OelkePeter Hur

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Citations

Sep 22, 2021·Current Medical Research and Opinion·Genevieve GauthierDario Ponce de Leon

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