Treatment to Prevent HIV Transmission in Serodiscordant Couples in Henan, China, 2006 to 2012

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
M Kumi SmithNing Wang

Abstract

Antiretroviral therapy (ART) administered in clinical trial settings virtually eliminates the sexual transmission of human immunodeficiency virus (HIV) in serodiscordant couples, but effectiveness of treatment as prevention in the community is debated. Conflicting results from previous analyses in a Chinese cohort underscore the importance of determining effectiveness of ART delivered in resource limited settings. All available years of data (2006-2012) from local disease control records of HIV patients and their seronegative spouses in Henan Province, China, were analyzed using marginal structural Cox models to estimate the effect of ART in the initially infected partner his or her partner's HIV seroconversion risk. We observed 157 seroconversion events in 4916 serosdiscordant couples, for an incidence rate of 0.59 cases per 100 person-years (PY) (95% confidence interval [CI], .51-.70). Of these, 84 occurred after the index partner had initiated ART (0.43/100PY; 95% CI, .35-.53) and 73, whereas index partners were untreated (5.87/100 PY; 95% CI, 4.65-7.42). In a marginal structural Cox model weighted for confounding and censoring, the hazard ratio (HR) for HIV transmission was 0.52 (95% CI, .34-.82). ART efficacy varied signif...Continue Reading

References

Apr 1, 1991·Statistics in Medicine·D B Rubin, N Schenker
Oct 31, 2003·American Journal of Epidemiology·Wayne A Ray
Mar 3, 2006·AIDS·Nicole CrepazUNKNOWN HIV/AIDS Prevention Research Synthesis (PRS) Team
Aug 7, 2008·American Journal of Epidemiology·Stephen R Cole, Miguel A Hernán
Apr 3, 2009·The New England Journal of Medicine·Mari M KitahataUNKNOWN NA-ACCORD Investigators
Jun 27, 2009·International Journal of Epidemiology·Ye MaRay Y Chen
Dec 17, 2009·Epidemiology·Miguel A Hernán
Feb 9, 2010·American Journal of Epidemiology·Daniel WestreichLisa P Jacobson
Jun 12, 2010·Lancet·Deborah DonnellUNKNOWN Partners in Prevention HSV/HIV Transmission Study Team
Mar 23, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Wang LuWang Ning
Jul 20, 2011·The New England Journal of Medicine·Myron S CohenUNKNOWN HPTN 052 Study Team
Jul 13, 2012·The New England Journal of Medicine·Jared M BaetenUNKNOWN Partners PrEP Study Team
Nov 29, 2012·Current Opinion in HIV and AIDS·Marco VitoriaNathan Ford
Nov 16, 2013·PloS One·Na HeUNKNOWN China National HIV Prevention Study Group
Jun 20, 2014·Journal of the International AIDS Society·Bruno HoenUNKNOWN 2013 French HIV expert group
Jul 24, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Huixin LiuNing Wang
Aug 26, 2014·Current HIV/AIDS Reports·Kathryn E Muessig, Myron S Cohen

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Citations

Apr 5, 2017·Current HIV/AIDS Reports·Laura QuilterJeanne Marrazzo
Apr 28, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alicia Gutierrez-ValenciaLuis F López-Cortés
Jun 27, 2019·The Journal of the Association of Nurses in AIDS Care : JANAC·Lahong JuXi Chen

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