Treatment with a herbal formula B401 enhances neuroprotection and angiogenesis in the R6/2 mouse model of Huntington's disease

Drug Design, Development and Therapy
Sheue-Er WangChung-Hsin Wu

Abstract

Huntington's disease (HD) is a neurodegenerative disease characterized by motor dysfunction and early death. Despite years of research, the mechanisms responsible for chronic neurodegeneration of HD remain elusive. Chinese traditional medicines might provide new insights or new therapy for HD. The Chinese herbal formula B401 is a well-known Taiwan-US patent formula and a health supplement for promoting blood circulation and enhancing brain function. This study aimed to elucidate the neuroprotective effects of the Chinese herbal formula B401 on the syndrome of HD. Then, we compared the life span and body weight of R6/2 HD mice with and without oral B401 treatment. The ameliorative effects of B401 on the symptom of HD mice were investigated through behavior tests. Expressions of proteins for neuroprotection, angiogenesis, and inflammation in the brain tissue of R6/2 HD mice were compared by using immunostaining and Western blotting techniques. Our study in vitro showed that viabilities of glutamate-treated SH-SY5Y cells were significantly increased under B401 treatment. Our results in vivo showed that duration of survival was increased, body weight loss was reduced, and motor ability was improved in R6/2 HD mice under oral B401 t...Continue Reading

Citations

Oct 21, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Chih-Hsiang HsuChung-Hsin Wu
Jul 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Chung-Hsin WuMing-Chung Lee

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

Moor
Vitrea Core
- FLPI
ImageJ

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