Treatment With a Marine Oil Supplement Alters Lipid Mediators and Leukocyte Phenotype in Healthy Patients and Those With Peripheral Artery Disease.

Journal of the American Heart Association
Melinda S SchallerMichael S Conte

Abstract

Background Peripheral artery disease (PAD) is an advanced form of atherosclerosis characterized by chronic inflammation. Resolution of inflammation is a highly coordinated process driven by specialized pro-resolving lipid mediators endogenously derived from omega-3 fatty acids. We investigated the impact of a short-course, oral, enriched marine oil supplement on leukocyte phenotype and biochemical mediators in patients with symptomatic PAD and healthy volunteers. Methods and Results This was a prospective, open-label study of 5-day oral administration of an enriched marine oil supplement, assessing 3 escalating doses in 10 healthy volunteers and 10 patients with PAD. Over the course of the study, there was a significant increase in the plasma level of several lipid mediator families, total specialized pro-resolving lipid mediators, and specialized pro-resolving lipid mediator:prostaglandin ratio. Supplementation was associated with an increase in phagocytic activity of peripheral blood monocytes and neutrophils. Circulating monocyte phenotyping demonstrated reduced expression of multiple proinflammatory markers (cluster of differentiation 18, 163, 54, and 36, and chemokine receptor 2). Similarly, transcriptional profiling of mo...Continue Reading

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Citations

Sep 5, 2020·Essays in Biochemistry·Nan Chiang, Charles N Serhan
Apr 30, 2021·Pharmacology & Therapeutics·Dipak PanigrahyKhosrow Kashfi
Jul 10, 2021·Circulation Research·Duco Steven KoenisJesmond Dalli
Jul 10, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Ivan HartlingMartin Hersberger

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Methods Mentioned

BETA
blood draw
flow cytometry
PCR
acetylation

Clinical Trials Mentioned

NCT02719665

Software Mentioned

Bio
REDUCE
MetaboAnalyst
Rad CFX Analysis software
DA
Stata
PLS
SAS
Metagenics

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