PMID: 9531231Apr 8, 1998Paper

Treatment with alendronate prevents fractures in women at highest risk: results from the Fracture Intervention Trial

Archives of Internal Medicine
K E EnsrudD B Karpf

Abstract

The efficacy of antiresorptive therapy in preventing fractures in women at highest fracture risk, such as very elderly women or those with severe osteoporosis, is uncertain. Using data from a double-blind, randomized, placebo-controlled clinical trial that enrolled 2027 postmenopausal women aged 55 to 81 years with low femoral neck bone mineral density (BMD) and existing vertebral fractures, we examined the consistency of the effect of treatment with alendronate sodium in preventing fractures within a priori-specified risk subgroups defined at baseline by age, bone density, number of preexisting vertebral fractures, and history of postmenopausal fracture. The women were randomized to oral administration of alendronate or placebo and followed up for an average of 2.9 years. The initial dose of alendronate sodium was 5 mg/d; the dosage was increased from 5 to 10 mg/d at 24 months. New vertebral fractures, the primary end point of this arm of the trial, were defined by morphometry as a decrease of 20% and at least 4 mm in any vertebral height between baseline and a follow-up radiograph at 36 months. Incident clinical fractures, the secondary end point, included nonspine and clinical (symptomatic) vertebral fractures. All clinical ...Continue Reading

Citations

Jul 4, 2007·Aging Clinical and Experimental Research·M Jesús Moro Alvarez, Manuel Díaz-Curiel
Jun 2, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Adrianne C FeldsteinMikel Aickin
Mar 8, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N D NguyenT V Nguyen
Sep 19, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K ImaiK Nakamura
Mar 18, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R D Chapurlat, P D Delmas
Nov 26, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T P IpA W C Kung
Aug 21, 2007·Journal of Bone and Mineral Metabolism·Kazuhiro ImaiToshiyuki Horiuchi
May 7, 2008·Journal of General Internal Medicine·Kathryn M RyderUNKNOWN Fracture Intervention Trial Research Group
Nov 11, 2003·Comprehensive Therapy·Kelly A McGarryMichele G Cyr
Mar 18, 2000·Archives of Physical Medicine and Rehabilitation·P A LimT H Oh
Oct 26, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·J J Stĕpán, J Vokrouhlická
Jul 21, 1998·Endocrinology and Metabolism Clinics of North America·N B Watts
Sep 15, 2001·Annals of Epidemiology·K C AbbottW E Duncan
Jul 16, 1999·Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health·C A RaabC Snow
Aug 26, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Roland D Chapurlat, Pierre D Delmas
Dec 7, 2006·AIDS Research and Human Retroviruses·George PanJay M McDonald
Jul 1, 2006·Journal of General Internal Medicine·Alvah R CassCarol A Carlson
Jul 1, 2006·Journal of General Internal Medicine·Kathryn M RyderUNKNOWN Health ABC Study
Jan 13, 2001·BMJ : British Medical Journal·S E Straus
Aug 16, 2003·BMJ : British Medical Journal·A Cranney
May 11, 2006·BMC Family Practice·Robert J Petrella, Tim J Jones
Mar 26, 2010·BMC Musculoskeletal Disorders·Daniel AlbertssonRobert Eggertsen
Nov 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·V BreuilD W Dempster
Apr 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T MashibaD B Burr
Apr 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R S Weinstein
Apr 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C M KlotzbuecherM Berger
Oct 5, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B J RiisC Christiansen
Jan 31, 2007·Annals of Family Medicine·Daniel M AlbertssonRobert Eggertsen
May 3, 2011·PloS One·Elizabeth A ScovilleVictor M Montori
Nov 23, 2000·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·H K GenantJ A Shepherd
Jan 13, 2004·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Anna M SawkaCharlie H Goldsmith
Jan 23, 1999·Pharmacotherapy·M B O'Connell
Jan 20, 2012·The Journal of Bone and Joint Surgery. American Volume·Zvi SchwartzBarbara D Boyan

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