Treatment with alfacalcidol in elderly people significantly decreases the high risk of falls associated with a low creatinine clearance of <65 ml/min

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Laurent DukasH B Stähelin

Abstract

We previously observed that a creatinine clearance (CrCl) of <65 ml/min is a significant and independent risk factor for the number of fallers and falls in a community-dwelling elderly population and postulated that this increased risk is due to the associated significant lower D-hormone serum levels. To test our hypothesis, we investigated in a post hoc analysis of a double-blind randomized study whether treatment with alfacalcidol, a synthetic prodrug of the D-hormone, can reduce the high incidence of fallers and the high risk of falls associated with low CrCl. Of 378 Swiss community-dwelling women (n=191) and men (n=187), aged 70 years and older, 191 received randomly 1 microg capsules of alfacalcidol (AlphaD3: Teva), and 187 received one capsule of placebo daily. With the help of questionnaires we regularly assessed the incidence and frequency of falls. The risk of becoming a faller and the risk of falling were assessed in multivariate-controlled logistic regression models according to treatment groups and according to a CrCl cut-off of 65 ml/min. The presented results are from ITT analyses. In participants with a CrCl of <65 ml/min, the 36 weeks of treatment with alfacalcidol was, compared with placebo, associated with a s...Continue Reading

References

Jan 1, 1992·Annual Review of Public Health·R W Sattin
May 12, 1989·JAMA : the Journal of the American Medical Association·M C NevittD Black
Nov 1, 1986·Endocrine Reviews·R Boland
Jan 1, 1986·Bone·S EpsteinC C Johnston
Jun 1, 1984·The Journal of Clinical Investigation·K S TsaiB L Riggs
Aug 13, 1981·The New England Journal of Medicine·D M SlovikJ T Potts
Dec 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G PoórL J Melton
Apr 1, 1998·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M E Tinetti, C S Williams
Jan 23, 1999·Archives of Physical Medicine and Rehabilitation·H A BischoffR Theiler
Oct 16, 1999·Journal of the American Geriatrics Society·M S SteinL Flicker
Feb 24, 2001·Aging : Clinical and Experimental Research·H J VerhaarS A Duursma
Aug 15, 2001·The Journal of Clinical Endocrinology and Metabolism·J C GallagherS S Sherman
May 15, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J K DhesiT J Allain
Jan 3, 2003·The New England Journal of Medicine·Mary E Tinetti
Feb 11, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R KorpelainenS Keinänen-Kiukaanniemi
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Anne R CappolaLinda P Fried
Nov 11, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mio KoikeYoshiki Seino

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Citations

Jun 4, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Laurent DukasHannes B Stähelin
Apr 17, 2010·Journal of the American Society of Nephrology : JASN·Thomas L NickolasElizabeth Shane
Jan 24, 2007·The Journal of Steroid Biochemistry and Molecular Biology·J C GallagherLynette Smith
Jan 23, 2009·Rheumatology International·J D Ringe, E Schacht
Sep 23, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L DukasM Runge
May 7, 2015·Journal of Bone and Mineral Metabolism·Hayato KinoshitaYoichi Shimada
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Lesley D GillespieSarah E Lamb
Apr 15, 2014·The Cochrane Database of Systematic Reviews·Alison AvenellDianne O'Connell
Jan 19, 2013·Endocrine Journal·Ichiro TatsunoMakio Shozu
Mar 15, 2006·Mayo Clinic Proceedings·Michael F Holick

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