Treatment with AM3 restores defective T-cell function in COPD patients

Chest
Eduardo ReyesMelchor Alvarez-Mon

Abstract

Lymphocyte alterations have been associated with an increased prevalence of acute respiratory infections in COPD patients. AM3 is an oral immunomodulator that normalizes the defective functions of peripheral blood natural killer and phagocytic cells in COPD patients and improves their health-related quality of life. To characterize putative systemic abnormalities of the T-cell compartment in COPD patients, and to investigate whether AM3 can restore such abnormalities. The study was a randomized, prospective, double-blind, placebo-controlled trial in a cohort of COPD patients. The results were also compared to those of nonsmoker and ex-smoker healthy control subjects. Outpatient departments of four hospitals. Seventy COPD patients were randomized to receive either AM3 or a placebo orally for 90 consecutive days. Populations of 36 healthy nonsmokers and 36 healthy ex-smokers were used as control subjects. Peripheral blood mononuclear cell (PBMC) proliferation and production of interleukin (IL)-2, IL-4, IL-12p40, tumor necrosis factor-alpha, and interferon (IFN)-gamma proteins in response to the T-cell polyclonal mitogens were assessed at baseline and at the end of treatment. The proliferative response was significantly decreased ...Continue Reading

References

May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·J BellaM G Rossmann
May 29, 1998·American Journal of Respiratory and Critical Care Medicine·T A SeemungalJ A Wedzicha
May 6, 1999·Current Opinion in Pulmonary Medicine·H Y Reynolds
Jul 27, 2000·The New England Journal of Medicine·P J Barnes
Dec 6, 2000·The European Respiratory Journal·T A SeemungalJ A Wedzicha
Feb 24, 2001·The New England Journal of Medicine·R W Schrier, R O Estacio
May 24, 2001·American Journal of Respiratory and Critical Care Medicine·M SaettaL M Fabbri
Nov 3, 2001·The Journal of Allergy and Clinical Immunology·J Y ChoD H Broide
Apr 23, 2002·Kidney International·Rafael Pérez-GarcíaMelchor Alvarez-Mon
May 1, 2002·Current Opinion in Pulmonary Medicine·Herbert Y Reynolds
May 16, 2002·Chest·Emil F M WoutersAnnemie M W J Schols
Jul 20, 2002·Critical Care Medicine·David J Dries, John F Perry
Oct 3, 2002·Annual Review of Medicine·Peter J Barnes
Feb 7, 2003·Current Pharmaceutical Design·P T Reid, J-M Sallenave
Mar 1, 2003·The European Respiratory Journal·A G N AgustíX Busquets
Apr 23, 2003·The Practitioner·Eric Livingston, Neil C Thomson
May 17, 2003·BMJ : British Medical Journal·David Price, Martin Duerden
Jul 2, 2003·Expert Opinion on Investigational Drugs·W I de Boer
Oct 3, 2003·Lancet·P M A Calverley, Paul Walker
Oct 18, 2003·Cytokine & Growth Factor Reviews·Peter J Barnes
Nov 14, 2003·Journal of Managed Care Pharmacy : JMCP·Michael T HalpernJordana K Schmier
Feb 13, 2004·Respiratory Medicine·Nikolaos TzanakisNikolaos M Siafakas
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katrin D MayerMarkus Mohrs

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Citations

Jun 5, 2007·American Journal of Respiratory and Critical Care Medicine·Klaus F RabeLeonardo M Fabbri
Sep 3, 2013·Respiratory Medicine·Sergio ScriminiJaume Sauleda
Apr 17, 2008·British Journal of Pharmacology·S Martín-VilchezP L Majano
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xuehai ZhuSteven R Duncan
Jul 6, 2021·Frontiers in Immunology·Diego Fernández-LázaroMarcela González-Gross

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