Treatment with atorvastatin attenuates progression of insulin resistance and pancreatic fibrosis in the Otsuka Long-Evans Tokushima fatty rats

Metabolism: Clinical and Experimental
Limin WeiMakoto Otsuki

Abstract

The effects of statins on insulin resistance (IR) and type 2 diabetes mellitus (T2DM) are still controversial and its effects on pancreatic fibrosis are poorly defined. The purpose of this study is to examine the effects of atorvastatin on these issues using the Otsuka Long-Evans Tokushima Fatty (OLETF) rat, an animal model of IR, T2DM and pancreatic fibrosis. Male OLETF rats were divided into 2 groups at 6weeks of age. The first group received a standard diet until the end of experimental period at age 28weeks. The second group was given a diet containing 0.05% atorvastatin from 6weeks of age, before the onset of IR and pancreatic fibrosis. The age-matched Long-Evans Tokushima Otsuka rats without presence of IR, T2DM and pancreatic fibrosis, received a standard diet and were used as a normal control. Atorvastatin slightly decreased serum fasting glucose and insulin levels, but significantly improved index of IR compared with the untreated OLETF rats. In addition, atorvastatin markedly decreased transforming growth factor-β1 mRNA expression, myeloperoxidase activity and proportion of fibrotic area, and elevated superoxide dismutase activity in the pancreas compared with the untreated OLETF rats. These findings suggest that ator...Continue Reading

References

Jun 1, 1981·American Journal of Clinical Pathology·S M HsuH Fanger
Apr 18, 1998·Gastroenterology·C P Day, O F James
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·J K KimG I Shulman
Mar 6, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·José-Antonio GómezJuan-R Malagelada
Aug 18, 2004·Journal of the American College of Cardiology·Yang YuMasakazu Kohno
Feb 5, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Madhav BhatiaAngelo Guglielmotti
Jul 1, 2005·Metabolism: Clinical and Experimental·Marie-Hélène Gannagé-YaredGeorges Halaby
Jul 7, 2005·Atherosclerosis·Victor WongGary F Lewis
Nov 8, 2005·Biological & Pharmaceutical Bulletin·Kumi SatohKazuo Ichihara
Jun 14, 2006·Developmental Psychobiology·Timothy H Moran, Sheng Bi
Dec 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Yan ChenMasakazu Kohno
Mar 21, 2007·Digestive Diseases and Sciences·Xi-Ping ZhangYi-Feng Zhou
Mar 30, 2007·Atherosclerosis·Toshiyuki TakagiIichiro Shimomura
Nov 11, 2008·The New England Journal of Medicine·Paul M RidkerUNKNOWN JUPITER Study Group
Oct 6, 2009·Metabolism: Clinical and Experimental·Daniela T FuruyaUbiratan F Machado
Feb 26, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·R Scott RectorJamal A Ibdah
Mar 9, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Limin WeiMakoto Otsuki
Sep 29, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hideyuki HyogoSusumu Tazuma
May 23, 2012·Circulation·Pasquale PignatelliFrancesco Violi
Mar 20, 2014·Metabolism: Clinical and Experimental·Marilyne BraultStella S Daskalopoulou
Oct 15, 2014·Metabolism: Clinical and Experimental·Yongin ChoEun Seok Kang
Dec 9, 2014·Metabolism: Clinical and Experimental·Niki KatsikiChristos S Mantzoros

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