Treatment with crocin improves cardiac dysfunction by normalizing autophagy and inhibiting apoptosis in STZ-induced diabetic cardiomyopathy

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
K FeidantsisA Lazou

Abstract

The association of diabetes mellitus (DM) and poor metabolic control with high incidence of cardiovascular diseases is well established. The aim of this study was to investigate the potential cardioprotective effect of crocin (Crocus sativus L. extract) on diabetic heart dysfunction and to elucidate the mediating molecular mechanisms. Streptozotocin (STZ)-induced diabetic rats were treated with two different concentrations of crocin (10 or 20 mg/kg), while isolated cardiac myocytes exposed to 25 mM glucose, were treated with 1 or 10 μM of crocin. Treatment of STZ-diabetic rats with crocin resulted in normalization of plasma glucose levels, inhibition of cardiac hypertrophy and fibrosis, and improvement of cardiac contractile function. Heat Shock Response was enhanced. Myocardial AMPK phosphorylation was increased after treatment with crocin, resulting in normalization of autophagy marker proteins (LC3BII/LC3BI ratio, SQSTM1/p62 and Beclin-1), while the diabetes-induced myocardial apoptosis was decreased. Similar results regarding the effect of crocin on autophagy and apoptosis pathways were obtained in isolated cardiac myocytes exposed to high concentration of glucose. The results suggest that crocin improves the deteriorated c...Continue Reading

Citations

Sep 25, 2020·Medicinal Research Reviews·Xiaoqian WuJiandong Luo
Mar 3, 2020·Frontiers in Pharmacology·Yun ChenGuoliang Meng
Nov 2, 2019·Pharmacological Reports : PR·Vafa Baradaran RahimVahid Reza Askari
May 24, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jinghui ZhaiSixi Zhang
Sep 2, 2020·Journal of Ethnopharmacology·Sadegh ShababMaryam Mahmoudabady
Apr 30, 2020·Saudi Journal of Biological Sciences·Mardi M Algandaby
Feb 1, 2020·Pharmacological Reports : PR·Vafa Baradaran RahimVahid Reza Askari
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Runze WangMingming Zhang
Apr 6, 2021·Journal of Cardiovascular and Thoracic Research·Soleyman BafadamMohammad Soukhtanloo
Nov 21, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lian LiuBo Zhao
Aug 1, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Shahzad KhanMohammad A Kamal

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