Treatment with dehydroepiandrosterone (DHEA) stimulates oxidative energy metabolism in the cerebral mitochondria. A comparative study of effects in old and young adult rats

Neuroscience Letters
Minal A Patel, S S Katyare

Abstract

The content of the neurosteroids, dehydroepiandrosterone (DHEA) in the brain decreases with aging. Also the oxidative energy metabolism is known to decrease with aging. Hence we examined the effects of treatment with DHEA (0.2 or 1.0 mg/kg body weight for 7 days) on oxidative energy metabolism in brain mitochondria from old and young adult rats. State 3 respiration rates in brain mitochondria from old animals were considerably lower than those in young adults. Treatment with DHEA stimulated state 3 and state 4 respiration rates in both the groups of the animals in a dose-dependent manner. In the old rats following DHEA treatment, the state 3 respiration rates became comparable to or increased beyond those of untreated young adults. In contrast to the old rats, stimulatory effect of DHEA treatment was of greater magnitude in the young adults. However, at higher dose (1.0 mg) the effect declined. Cytochrome aa3 content in the brain mitochondria from old rats was significantly low but the content of cytochrome b was unchanged while the content of cytochromes c+c1 had increased. Treatment with DHEA increased the content of cytochrome aa3 and b in old as well as in young adult animals. Higher dose of DHEA (1.0 mg) had adverse effect...Continue Reading

References

Jul 1, 1977·Archives of Biochemistry and Biophysics·S S KatyareA Sreenivasan
May 30, 1990·Mechanisms of Ageing and Development·M Subramanian, S S Katyare
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C CorpéchotE E Baulieu
Nov 1, 1981·Stroke; a Journal of Cerebral Circulation·J AstrupH R Sørensen
May 1, 1980·Mechanisms of Ageing and Development·D R Deshmukh, M S Patel
Jan 1, 1996·Annual Review of Biochemistry·R O Poyton, J E McEwen
Sep 25, 1999·The Journal of Endocrinology·J P Hinson, P W Raven
Oct 13, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D Attwell, S B Laughlin
Nov 24, 2001·Respiration Physiology·M Erecińska, I A Silver
Nov 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Sébastien Weill-EngererYvette Akwa
Oct 11, 2003·World Journal of Urology·Jacques Buvat
Mar 25, 2004·Drug and Chemical Toxicology·Subhash D Katewa, Surendra S Katyare
Jul 16, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ana NavarroAlberto Boveris

❮ Previous
Next ❯

Citations

Mar 6, 2012·Human Nature : an Interdisciplinary Biosocial Perspective·Benjamin C Campbell
Jul 1, 2008·Indian Journal of Clinical Biochemistry : IJCB·Hiren R ModiSamir P Patel
Nov 23, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Claudia Vieira-MarquesMaria Flávia M Ribeiro
Sep 12, 2017·The Journal of Obstetrics and Gynaecology Research·Li-Te LinKuan-Hao Tsui
Mar 21, 2020·Frontiers in Endocrinology·Benjamin Campbell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.