Treatment with docosahexaenoic acid, but not eicosapentaenoic acid, delays Ca2+-induced mitochondria permeability transition in normal and hypertrophied myocardium.

The Journal of Pharmacology and Experimental Therapeutics
Ramzi J KhairallahWilliam C Stanley

Abstract

Intake of fish oil containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) prevents heart failure; however, the mechanisms are unclear. Mitochondrial permeability transition pore (MPTP) opening contributes to myocardial pathology in cardiac hypertrophy and heart failure, and treatment with DHA + EPA delays MPTP opening. Here, we assessed: 1) whether supplementation with both DHA and EPA is needed for optimal prevention of MPTP opening, and 2) whether this benefit occurs in hypertrophied myocardium. Rats with either normal myocardium or cardiac hypertrophy induced by 8 weeks of abdominal aortic banding were fed one of four diets: control diet without DHA or EPA or diets enriched with either DHA, EPA, or DHA + EPA (1:1 ratio) at 2.5% of energy intake for 17 weeks. Aortic banding caused a 27% increase in left ventricular mass and 25% depletion in DHA in mitochondrial phospholipids in rats fed the control diet. DHA supplementation raised DHA in phospholipids ∼2-fold in both normal and hypertrophied hearts and increased EPA. DHA + EPA supplementation also increased DHA, but to a lesser extent than DHA alone. EPA supplementation increased EPA, but did not affect DHA compared with the control diet. Ca(2+)-induced MPTP op...Continue Reading

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Citations

Nov 20, 2013·Chemico-biological Interactions·Béatrice DendeléDominique Lagadic-Gossmann
Nov 10, 2011·Cardiovascular Research·Ganesh V HaladeMerry L Lindsey
Jan 20, 2011·Molecular and Cellular Biology·Kyriakos N PapanicolaouKenneth Walsh
Aug 7, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Kathleen GuglielminoFlorin Despa
Oct 30, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Tatiana F GalvaoWilliam C Stanley
Dec 18, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Girma AsemuWilliam C Stanley
Mar 3, 2012·Circulation Research·William C StanleyKelly A O'Connell
Apr 12, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Bruno Le GrandStanley Nattel
Sep 26, 2013·Journal of Cardiovascular Translational Research·William C StanleyChristine des Rosiers
May 20, 2014·The Journal of Nutritional Biochemistry·Myra E Woodworth-HobbsS Russ Price
Mar 5, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Takhar KasumovWilliam C Stanley
Apr 23, 2013·Drug Metabolism Reviews·Abdulaziz M S AlsaadAyman O S El-Kadi
Jun 20, 2012·The International Journal of Biochemistry & Cell Biology·Kaïs H Al-Gubory
Apr 3, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Saame Raza Shaikh, David A Brown
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Aug 21, 2019·International Journal of Molecular Sciences·Atsushi SakamotoYuichiro Maekawa
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Jun 27, 2012·Molecular Biology Reports·Do Kyun KimKi-Chul Hwang

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