PMID: 6404441Apr 23, 1983Paper

Treatment with gonadotrophin releasing hormone analogue in advanced prostatic cancer

British Medical Journal
J WaxmanR T Oliver

Abstract

Repeated administration of long acting analogues of gonadotrophin releasing hormone diminishes gonadal function and in men decreases testosterone concentrations; for this reason the effect of the analogue buserelin was studied in prostatic carcinoma. Twelve consecutive patients with newly diagnosed locally advanced or metastatic carcinoma of the prostate were treated. Each patient received intranasal buserelin in divided dosages of either 600 or 1000 micrograms daily. Suppression of the gonadotrophins and testosterone occurred in all patients. Objective and subjective signs of regression of disease were seen in nine patients. Buserelin offers an effective treatment of metastatic prostatic cancer without the side effects and cardiovascular risks associated with oestrogen treatment.

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Citations

Jan 1, 1995·Critical Reviews in Oncology/hematology·M Koutsilieris
Aug 15, 2001·Urology·G J Bubley
Oct 15, 1983·Lancet·D R Chadha, A Matroos
Jan 1, 1991·Progress in Growth Factor Research·A QayumJ Waxman
Mar 30, 2007·Nature Clinical Practice. Oncology·Mary-Ellen Taplin
Nov 15, 1984·The New England Journal of Medicine·UNKNOWN Leuprolide Study Group
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M Mason-GarciaA V Schally
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A V Schally, T W Redding
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A V SchallyJ I Paz-Bouza
Jan 1, 1990·British Journal of Urology·J WaxmanG Williams
Feb 11, 1984·British Medical Journal·J Waxman
Sep 8, 1984·British Medical Journal·G Williams, S R Bloom
Jul 1, 1991·Journal of Endocrinological Investigation·P ValensiJ Sebaoun
Sep 2, 2008·Expert Review of Anticancer Therapy·Mary-Ellen Taplin
Jan 1, 1987·Cancer Investigation·B S HilarisM Batata
Mar 1, 1987·British Journal of Urology·H ParmarS L Lightman
Dec 1, 1984·British Journal of Urology·A D MeeK Mashiter
Jan 1, 1988·Critical Reviews in Oncology/hematology·L J SwansonM B Garnick
Aug 1, 1987·Cancer·J T GrayhackJ M Kozlowski

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