Treatment with granulocyte colony-stimulating factor in patients with repetitive implantation failures and/or recurrent spontaneous abortions

Journal of Reproductive Immunology
Wolfgang Würfel

Abstract

Granulocyte colony-stimulating factor (G-CSF) belongs to the family of colony-stimulating factors (CSF). As the name suggests, it was initially identified as being able to target and influence granulopoiesis, but was soon shown to be a ubiquitous growth factor, with synthesis and receptors, such as the related granulocyte macrophage colony-stimulating factor (GM-CSF), which is found in a wide variety of tissue types, including the organs and cell populations involved in reproduction. It must now be assumed that both G-CSF and GM-CSF control, or play a role in controlling, key processes in oocyte and sperm maturation, endometrial receptivity, implantation, and embryo and fetal development, possibly extending to birth. The following article offers an overview of the current findings with regard to animal experimental studies, initial clinical applications in reproductive medicine, and potential risks.

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Citations

May 14, 2016·Journal of Assisted Reproduction and Genetics·Frances Grimstad, Sacha Krieg
Oct 14, 2016·PloS One·Ricardo C CavalliHernan D Kopcow
Nov 5, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Samaneh Abdolmohammadi-VahidMehdi Yousefi
Apr 1, 2018·American Journal of Reproductive Immunology : AJRI·Hamed HajipourMohammad Nouri
Jan 25, 2020·The Cochrane Database of Systematic Reviews·Mohan S KamathSesh Kamal Sunkara
Sep 10, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Hulusi Bulent ZeynelogluUtkun Moran
Mar 22, 2020·Scientific Reports·Ziya KalemTimur Gurgan

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