PMID: 9003214Jan 1, 1997Paper

Treatment with hot, humid air reduces the nasal response to allergen challenge

The Journal of Allergy and Clinical Immunology
M DesrosiersR M Naclerio

Abstract

Ten subjects with asymptomatic seasonal allergy, outside of their allergy season, underwent allergen provocation following 1 hour of exposure to air at either 20 degrees C and 30% relative humidity (RH) or air at 37 degrees C and 90% RH. The ipsilateral changes following antigen challenge were compared under the two conditions. Conditioning of the nose to 37 degrees C, 90% RH reduced total histamine release (7.9 +/- 1.8 ng vs 4.2 +/- 1.3 ng; p < or = 0.05), sneezes (6 +/- 2 vs 3 +/- 1; p < or = 0.05), pruritus (score of 17.4 +/- 6.0 vs score of 2.0 +/- 1.8 out of a total score of 100, p < or = 0.01), nasal airway resistance (1.4 +/- 0.8 kPa/L/sec vs 0.2 +/- 0.1 kPa/L/sec; p < or = 0.05), human serum albumin levels (389.6 +/- 53.4 micrograms vs 242.2 +/- 37.9 micrograms; p < or = 0.05), and congestion (score of 23.8 +/- 4.8 vs score of 10.6 +/- 5.4 out of a total score of 100, p < or = 0.01). It had no effect on the volume of secretions (p = 0.8), lactoferrin levels (p = 0.3), or rhinorrhea (p = 1.0). Thus air at 37 degrees C and 90% RH partially reduces the early response to antigen. Its effects are greatest on histamine release, the vascular response, and neural responses, with no effect on the glandular response. The mechanis...Continue Reading

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Feb 1, 1996·The Annals of Otology, Rhinology, and Laryngology·M DesrosiersR M Naclerio
Feb 15, 1957·The Journal of Physiology·J L MONGAR, H O SCHILD

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Citations

Jan 1, 1997·Allergy·R M Naclerio
Mar 21, 2013·Journal of Paediatrics and Child Health·Hyeong Yun KimMan Yong Han
Dec 12, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P AssanasenR M Naclerio
May 15, 2010·Canadian Journal on Aging = La Revue Canadienne Du Vieillissement·Nathalie Bailly, Nicolas Roussiau

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