PMID: 8985778Oct 1, 1996Paper

Treatment with human chorionic gonadotrophin for cryptorchidism: clinical and histological effects

International Journal of Andrology
Marko KalevaJ Toppari

Abstract

The efficacy of hCG treatment was studied in 182 cryptorchid patients. The efficacy of the treatment correlated with the initial position of the testis. None of the abdominal testes reached a normal position, whereas 90% of high scrotal testes descended during the treatment. Fifty-four boys who were treated unsuccessfully with hCG and 29 untreated boys were biopsied. The biopsies were performed on 32 scrotal and 87 maldescended testes to examine the state of the organ and the effects of hCG treatment. In biopsies, the volume densities of seminiferous tubules, interstitial tissue and blood vessels were counted, and the sections screened for interstitial bleeding. Significant differences between scrotal and maldescended testes were found in all of the volume densities measured. Interstitial bleeding occurred rarely in scrotal testes, whereas in maldescended testes it was frequently apparent. hCG treatment induced a significant increase in the volume density of both interstitial tissue and blood vessels. Even though the hCG treatment induced measurable, possibly harmful, changes both in scrotal and maldescended testes, our data do not prove that hCG treatment causes permanent damage to the testis.

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Citations

Jun 21, 2005·Cell and Tissue Research·Marko Kaleva, Jorma Toppari
Mar 3, 2007·Apoptosis : an International Journal on Programmed Cell Death·Dinesh K GautamN Sehgal
Feb 23, 2012·Apoptosis : an International Journal on Programmed Cell Death·Ankur MaheshwariRajnesh K Sharma
Jan 16, 2007·European Journal of Endocrinology·Taneli RaivioLeo Dunkel
May 3, 2014·Annales d'endocrinologie·Jorma ToppariHelena E Virtanen
May 10, 2007·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Charbel S El ZoghbiFrancisco J B Sampaio
Apr 28, 2007·Acta Paediatrica·Anders Bergh, Olle Söder
Aug 10, 2019·Frontiers in Endocrinology·Tanja Kuiri-HänninenUlla Sankilampi
Sep 4, 2003·Journal of Endocrinological Investigation·F Brucker-DavisP Fenichel

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