Treatment with Hydroxychloroquine vs Hydroxychloroquine + Nitazoxanide in COVID-19 patients with risk factors for poor prognosis: A structured summary of a study protocol for a randomised controlled trial

Trials
José Meneses CalderónSrivatsan Padmanabhan

Abstract

To determine the efficacy of Hydroxychloroquine vs. Hydroxychloroquine + Nitazoxanide in reducing the need for invasive mechanical ventilatory support for patients with COVID-19. Hydroxychloroquine is currently being used in multiple trials with varying doses in an attempt to treat COVID-19. Nitazoxanide has powerful antiviral effects and proven efficacy against a range of viruses including SARS and MERS. Dual therapy by combining appropriate doses of these two medications with diverse activities against COVID-19 is expected to be better than monotherapy with hydroxychloroquine. This is a single centre, randomized, controlled, single blinded, 2 arm (ratio 1:1) parallel group trial. 86 COVID-19 positive patients that are being treated at the Health Institute of the State of Mexico (ISEM) in Toluca, State of Mexico will be recruited from May 14 to December 31, 2020. 1)Age older than 18 years.2)Hospitalised COVID-19 PCR test positive patients.3)Within the first 72 hours after performing the PCR test.4)Presence of risk factors for complications (at least one): over 60 years, history of diabetes mellitus, hypertension, and morbid obesity. 1)Patients with corrected QT interval (QTc) greater than 500ms at hospital admission.2)Patients...Continue Reading

Associated Clinical Trials

Citations

Aug 6, 2020·Journal of Biomolecular Structure & Dynamics·Arif Jamal SiddiquiMohd Adnan
Apr 17, 2020·Postgraduate Medical Journal·Neeraj Sinha, Galit Balayla
Sep 6, 2020·Pharmacological Reports : PR·Thakur Uttam SinghRaj Kumar Singh
Sep 24, 2020·Revista da Associação Médica Brasileira·Lincoln Lopes FerreiraWanderley Marques Bernardo
Oct 2, 2020·Current Opinion in HIV and AIDS·Ivan F N Hung
Dec 29, 2020·Frontiers in Pharmacology·Nour K YounisMariam Arabi
May 4, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Devendra Kumar, Neerja Trivedi
Nov 24, 2021·Future Microbiology·Khatereh ZarkeshFatemeh Farjadian

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